Literature DB >> 29309929

FoxO transcription factors in cancer metabolism.

Raj Kumar Yadav1, Anoop Singh Chauhan2, Li Zhuang1, Boyi Gan3.   

Abstract

FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer metabolism; FoxO; Myc; Tumor suppression; mTOR

Mesh：

Substances：

Year:  2018        PMID： 29309929      PMCID： PMC5986595          DOI： 10.1016/j.semcancer.2018.01.004

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  183 in total

1.  FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress.

Authors:  Yoko Furukawa-Hibi; Kiyomi Yoshida-Araki; Tsutomu Ohta; Kyoji Ikeda; Noboru Motoyama
Journal:  J Biol Chem       Date:  2002-06-04       Impact factor: 5.157

2.  Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death.

Authors:  Qi Xie; Yumin Hao; Li Tao; Shengyi Peng; Chitong Rao; Hong Chen; Han You; Meng-qiu Dong; Zengqiang Yuan
Journal:  EMBO Rep       Date:  2012-04       Impact factor: 8.807

3.  FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.

Authors:  Walbert J Bakker; Isaac S Harris; Tak W Mak
Journal:  Mol Cell       Date:  2007-12-28       Impact factor: 17.970

4.  The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.

Authors:  T Maehama; J E Dixon
Journal:  J Biol Chem       Date:  1998-05-29       Impact factor: 5.157

5.  Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.

Authors:  Nagalingam R Sundaresan; Madhu Gupta; Gene Kim; Senthilkumar B Rajamohan; Ayman Isbatan; Mahesh P Gupta
Journal:  J Clin Invest       Date:  2009-08-03       Impact factor: 14.808

6.  FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

Authors:  Armando van der Horst; Leon G J Tertoolen; Lydia M M de Vries-Smits; Roy A Frye; René H Medema; Boudewijn M T Burgering
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157

7.  The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.

Authors:  Ahmed Essaghir; Nicolas Dif; Catherine Y Marbehant; Paul J Coffer; Jean-Baptiste Demoulin
Journal:  J Biol Chem       Date:  2009-02-24       Impact factor: 5.157

Review 8.  The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Authors:  Rachel L Wolfson; David M Sabatini
Journal:  Cell Metab       Date:  2017-08-01       Impact factor: 27.287

9.  The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.

Authors:  V M Renault; P U Thekkat; K L Hoang; J L White; C A Brady; D Kenzelmann Broz; O S Venturelli; T M Johnson; P R Oskoui; Z Xuan; E E Santo; M Q Zhang; H Vogel; L D Attardi; A Brunet
Journal:  Oncogene       Date:  2011-03-21       Impact factor: 9.867

10.  FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

Authors:  Han You; Marc Pellegrini; Katsuya Tsuchihara; Kazuo Yamamoto; Georg Hacker; Miriam Erlacher; Andreas Villunger; Tak W Mak
Journal:  J Exp Med       Date:  2006-06-26       Impact factor: 14.307
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  31 in total

1.  Deciphering the involvement of iron targets in colorectal cancer: a network biology approach.

Authors:  Abdul Arif Khan; Mohd Tashfeen Ashraf; Fahad M Aldakheel; Ayca Sayi Yazgan; Rana Zaidi
Journal:  Am J Transl Res       Date:  2022-01-15       Impact factor: 4.060

2.  The expression and potential mechanism of EGFR and EZH2 in breast cancer.

Authors:  Xiaoqi Tang; Taosheng Zhou; Jiayue Shen; Ming Luo; Huiming Yuan; Denghua Pan; Fu Li
Journal:  Gland Surg       Date:  2021-08

3.  Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer.

Authors:  Lin Li; Xi Zhang; Yuqi Li; Bo Xiao; Sibiao Pei; Hangyu Jiang; Xiaofen Zhang
Journal:  Int J Mol Med       Date:  2022-07-07       Impact factor: 5.314

4.  Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis.

Authors:  Wei Guo; Xiaohui Yao; Siyuan Lan; Chi Zhang; Hanhan Li; Zhuangzhong Chen; Ling Yu; Guanxian Liu; Yuan Lin; Shan Liu; Hanrui Chen
Journal:  Chin Med       Date:  2022-06-20       Impact factor: 4.546

5.  Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).

Authors:  Yue Jia; Barbara French; Brittany Tillman; Samuel French
Journal:  Exp Mol Pathol       Date:  2018-07-17       Impact factor: 3.362

6.  Comprehensive and integrative analysis identifies microRNA-106 as a novel non-invasive biomarker for detection of gastric cancer.

Authors:  Qiliang Peng; Yi Shen; Kaisu Lin; Li Zou; Yuntian Shen; Yaqun Zhu
Journal:  J Transl Med       Date:  2018-05-15       Impact factor: 5.531

Review 7.  Targeting Transcription Factors for Cancer Treatment.

Authors:  Mélanie Lambert; Samy Jambon; Sabine Depauw; Marie-Hélène David-Cordonnier
Journal:  Molecules       Date:  2018-06-19       Impact factor: 4.411

Review 8.  Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER.

Authors:  Matteo Barberis
Journal:  NPJ Syst Biol Appl       Date:  2021-06-11

9.  Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

Authors:  Mahmoud AbuEid; Donna M McAllister; Laura McOlash; Megan Cleland Harwig; Gang Cheng; Donovan Drouillard; Kathleen A Boyle; Micael Hardy; Jacek Zielonka; Bryon D Johnson; R Blake Hill; Balaraman Kalyanaraman; Michael B Dwinell
Journal:  iScience       Date:  2021-05-25

Review 10.  The Dominant Role of Forkhead Box Proteins in Cancer.

Authors:  Duc-Hiep Bach; Nguyen Phuoc Long; Thi-Thu-Trang Luu; Nguyen Hoang Anh; Sung Won Kwon; Sang Kook Lee
Journal:  Int J Mol Sci       Date:  2018-10-22       Impact factor: 5.923
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