Vanessa Mello Granado Cassettari1, Nilton Carlos Machado2, Pedro Luiz Toledo de Arruda Lourenção3, Marry Assis Carvalho2, Erika Veruska Paiva Ortolan3. 1. Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Cirurgia, Botucatu, SP, Brazil. Electronic address: vmgranado@gmail.com. 2. Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Unidade de Gastroenterologia Pediátrica, Botucatu, SP, Brazil. 3. Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Cirurgia, Unidade de Cirurgia Pediátrica, Botucatu, SP, Brazil.
Abstract
OBJECTIVES: Evaluate the effect of combinations of green banana biomass and laxatives in children and adolescents with chronic constipation. METHODS: This was a randomized study of 80 children and adolescents with functional constipation according to the Rome IV Criteria, who were divided into five groups: (1) green banana biomass alone; (2) green banana biomass plus PEG 3350 with electrolytes; (3) green banana biomass plus sodium picosulfate; (4) PEG 3350 with electrolytes alone; and (5) sodium picosulfate alone. Primary outcome measure was the reduction of the proportion of patients with Bristol Stool Form Scale ratings 1 or 2. Secondary outcome measures were: increase of the proportion of >3 bowel movements/week and reduction of the proportion of fecal incontinence, straining on defecation, painful defecation, blood in stool, abdominal pain, and decreased laxative doses. RESULTS: On consumption of green banana biomass alone, a statistically significant reduction was observed in the proportion of children with Bristol Stool Form Scale rating 1 or 2, straining on defecation, painful defecation, and abdominal pain. Conversely, no reduction was observed in fecal incontinence episodes/week, blood in stool, and no increase was observed in the proportion of children with >3 bowel movements/week. The percentage of children who required decreased laxative dose was high when green banana biomass was associated with sodium picosulfate (87%), and PEG 3350 with electrolytes (63%). Green banana biomass alone and associated with laxatives was well tolerated, and no adverse effects were reported. CONCLUSION: Green banana biomass is advantageous as an adjunct therapy on functional constipation, mainly for reducing doses of laxatives.
RCT Entities:
OBJECTIVES: Evaluate the effect of combinations of green banana biomass and laxatives in children and adolescents with chronic constipation. METHODS: This was a randomized study of 80 children and adolescents with functional constipation according to the Rome IV Criteria, who were divided into five groups: (1) green banana biomass alone; (2) green banana biomass plus PEG 3350 with electrolytes; (3) green banana biomass plus sodium picosulfate; (4) PEG 3350 with electrolytes alone; and (5) sodium picosulfate alone. Primary outcome measure was the reduction of the proportion of patients with Bristol Stool Form Scale ratings 1 or 2. Secondary outcome measures were: increase of the proportion of >3 bowel movements/week and reduction of the proportion of fecal incontinence, straining on defecation, painful defecation, blood in stool, abdominal pain, and decreased laxative doses. RESULTS: On consumption of green banana biomass alone, a statistically significant reduction was observed in the proportion of children with Bristol Stool Form Scale rating 1 or 2, straining on defecation, painful defecation, and abdominal pain. Conversely, no reduction was observed in fecal incontinence episodes/week, blood in stool, and no increase was observed in the proportion of children with >3 bowel movements/week. The percentage of children who required decreased laxative dose was high when green banana biomass was associated with sodium picosulfate (87%), and PEG 3350 with electrolytes (63%). Green banana biomass alone and associated with laxatives was well tolerated, and no adverse effects were reported. CONCLUSION: Green banana biomass is advantageous as an adjunct therapy on functional constipation, mainly for reducing doses of laxatives.