Liang Wang1, Hong Jiang2,3, Amiram Grinvald4, Chaitra Jayadev5, Jianhua Wang2. 1. a Department of Biology, Krieger School of Arts and Sciences , Johns Hopkins University , Baltimore , MA , USA. 2. b Department of Ophthalmology, Bascom Palmer Eye Institute , University of Miami , Miami , FL , USA. 3. c Department of Neurology , University of Miami , Miami , FL , USA. 4. d Department of Neurobiology , Weizmann Institute of Science , Rehovot , Israel. 5. e Narayana Nethralaya Eye Institute , Bangalore , India.
Abstract
PURPOSE: To review the clinical applications and diagnostic value of the retinal function imager (RFI), briefly compare RFI to other optical imaging devices, and to describe recent developments. METHODS: The search words "Retinal Functional Imager," "optical imaging," "retina angiography," "avascular zone," "foveal avascular zone," and other closely related terms were used in PubMed to review current literature involving the RFI. RESULTS: The functions of the RFI were utilized in over 44 microvascular studies, which reported that the microvasculature may alter in velocity, morphology, and oximetry when affected by a number of ocular, neurological, or systemic diseases. Recently developed automatic algorithms for noninvasive angiography of large retinal regions, segmenting vessels, measuring blood flow, blood velocity, vessel diameter, and oximetry may enhance the clinical applications of the RFI. CONCLUSION: The RFI has been used to characterize the retinal microvasculature under various conditions of all prevalent retinal diseases in addition to some central nerve system (CNS) and systemic diseases. Applying the RFI in research and clinical settings should help earlier diagnosis, support disease prevention, and improve treatment management.
PURPOSE: To review the clinical applications and diagnostic value of the retinal function imager (RFI), briefly compare RFI to other optical imaging devices, and to describe recent developments. METHODS: The search words "Retinal Functional Imager," "optical imaging," "retina angiography," "avascular zone," "foveal avascular zone," and other closely related terms were used in PubMed to review current literature involving the RFI. RESULTS: The functions of the RFI were utilized in over 44 microvascular studies, which reported that the microvasculature may alter in velocity, morphology, and oximetry when affected by a number of ocular, neurological, or systemic diseases. Recently developed automatic algorithms for noninvasive angiography of large retinal regions, segmenting vessels, measuring blood flow, blood velocity, vessel diameter, and oximetry may enhance the clinical applications of the RFI. CONCLUSION: The RFI has been used to characterize the retinal microvasculature under various conditions of all prevalent retinal diseases in addition to some central nerve system (CNS) and systemic diseases. Applying the RFI in research and clinical settings should help earlier diagnosis, support disease prevention, and improve treatment management.
Authors: Boyu Gu; Xiaolin Wang; Michael D Twa; Johnny Tam; Christopher A Girkin; Yuhua Zhang Journal: Biomed Opt Express Date: 2018-07-12 Impact factor: 3.732
Authors: W A J Birkhoff; L van Manen; J Dijkstra; M L De Kam; J C van Meurs; A F Cohen Journal: Graefes Arch Clin Exp Ophthalmol Date: 2019-09-16 Impact factor: 3.117
Authors: Giovana Rosa Gameiro; Hong Jiang; Yi Liu; Yuqing Deng; Xiaoyan Sun; Bernardo Nascentes; Bernard Baumel; Tatjana Rundek; Jianhua Wang Journal: Eye Vis (Lond) Date: 2018-08-17