Benjamin H Natelson1, Diana Vu1, Jeremy D Coplan2, Xiangling Mao3, Michelle Blate1, Guoxin Kang3, Eli Soto4, Tolga Kapusuz4, Dikoma C Shungu3. 1. Department of Neurology, Mount Sinai Beth Israel, New York, NY. 2. Department of Psychiatry & Behavioral Sciences, State University of New York-Downstate Medical Center, Brooklyn NY. 3. Department of Radiology, Weill Medical College of Cornell University, New York, NY. 4. Department of Pain Medicine, Mount Sinai Beth Israel, New York, NY.
Abstract
BACKGROUND: Chronic fatigue syndrome (CFS) and fibromyalgia (FM) frequently have overlapping symptoms, leading to the suggestion that the same disease processes may underpin the two disorders - the unitary hypothesis. However, studies investigating the two disorders have reported substantial clinical and/or biological differences between them, suggesting distinct pathophysiological underpinnings. PURPOSE: The purpose of this study was to further add to the body of evidence favoring different disease processes in CFS and FM by comparing ventricular cerebrospinal fluid lactate levels among patients with CFS alone, FM alone, overlapping CFS and FM symptoms, and healthy control subjects. METHODS: Ventricular lactate was assessed in vivo with proton magnetic resonance spectroscopic imaging (1H MRSI) with the results normed across the 2 studies in which the data were collected. RESULTS: Mean CSF lactate levels in CFS, FM and CFS+FM did not differ among the three groups, but were all significantly higher than the mean values for control subjects. CONCLUSION: While patients with CFS, FM and comorbid CFS and FM can be differentiated from healthy subjects based on measures of CFS lactate, this neuroimaging outcome measure is not a viable biomarker for differentiating CFS from FM or from patients in whom symptoms of the two disorders overlap.
BACKGROUND: Chronic fatigue syndrome (CFS) and fibromyalgia (FM) frequently have overlapping symptoms, leading to the suggestion that the same disease processes may underpin the two disorders - the unitary hypothesis. However, studies investigating the two disorders have reported substantial clinical and/or biological differences between them, suggesting distinct pathophysiological underpinnings. PURPOSE: The purpose of this study was to further add to the body of evidence favoring different disease processes in CFS and FM by comparing ventricular cerebrospinal fluid lactate levels among patients with CFS alone, FM alone, overlapping CFS and FM symptoms, and healthy control subjects. METHODS: Ventricular lactate was assessed in vivo with proton magnetic resonance spectroscopic imaging (1H MRSI) with the results normed across the 2 studies in which the data were collected. RESULTS: Mean CSF lactate levels in CFS, FM and CFS+FM did not differ among the three groups, but were all significantly higher than the mean values for control subjects. CONCLUSION: While patients with CFS, FM and comorbid CFS and FM can be differentiated from healthy subjects based on measures of CFS lactate, this neuroimaging outcome measure is not a viable biomarker for differentiating CFS from FM or from patients in whom symptoms of the two disorders overlap.
Authors: Shelley A Weaver; Malvin N Janal; Nadine Aktan; John E Ottenweller; Benjamin H Natelson Journal: J Womens Health (Larchmt) Date: 2010-05 Impact factor: 2.681
Authors: Akifumi Kishi; Benjamin H Natelson; Fumiharu Togo; Zbigniew R Struzik; David M Rapoport; Yoshiharu Yamamoto Journal: Sleep Date: 2011-11-01 Impact factor: 5.849
Authors: Michael E Geisser; Cathy Strader Donnell; Frank Petzke; Richard H Gracely; Daniel J Clauw; David A Williams Journal: Psychosomatics Date: 2008 May-Jun Impact factor: 2.386
Authors: Slobodanka Pejovic; Benjamin H Natelson; Maria Basta; Julio Fernandez-Mendoza; Fauzia Mahr; Alexandros N Vgontzas Journal: BMC Neurol Date: 2015-04-12 Impact factor: 2.474
Authors: Jeremy D Coplan; Hassan M Fathy; Chadi G Abdallah; Sherif A Ragab; John G Kral; Xiangling Mao; Dikoma C Shungu; Sanjay J Mathew Journal: Neuroimage Clin Date: 2014-01-09 Impact factor: 4.881
Authors: Christina Mueller; Joanne C Lin; Sulaiman Sheriff; Andrew A Maudsley; Jarred W Younger Journal: Brain Imaging Behav Date: 2020-04 Impact factor: 3.978
Authors: Herbert Renz-Polster; Marie-Eve Tremblay; Dorothee Bienzle; Joachim E Fischer Journal: Front Cell Neurosci Date: 2022-05-09 Impact factor: 6.147
Authors: Francisco Javier Falaguera-Vera; María Garcia-Escudero; Javier Bonastre-Férez; Mario Zacarés; Elisa Oltra Journal: Int J Environ Res Public Health Date: 2020-10-31 Impact factor: 3.390
Authors: Zack Y Shan; Leighton R Barnden; Richard A Kwiatek; Sandeep Bhuta; Daniel F Hermens; Jim Lagopoulos Journal: J Transl Med Date: 2020-09-01 Impact factor: 5.531
Authors: Beata R Godlewska; Stephen Williams; Uzay E Emir; Chi Chen; Ann L Sharpley; Ana Jorge Goncalves; Monique I Andersson; William Clarke; Brian Angus; Philip J Cowen Journal: Psychopharmacology (Berl) Date: 2021-10-05 Impact factor: 4.530