OBJECTIVE: Various genetic and environmental risk factors have been shown to be associated with the incidence of rheumatic diseases. However, the pathogenesis of rheumatic diseases poorly understood. Several studies have shown associations of ABO blood groups with various diseases. Our study aimed to determine whether there is an association between the types of rheumatic diseases and ABO and Rh blood groups. MATERIAL AND METHODS: The study included the patients, followed up at the Immunology-Rheumatology clinic between January 2016 and December 2016 for diagnosis of rheumatic disease, who had an ABO Rh blood data. Age, gender, type of rheumatic disease, ABO Rh blood groups were recorded. RESULTS: When 823 patients were assessed for blood types, 42.5% patients had A type, 33.2% had O type, 15.4% had B type, and 8.9% had AB type. There was significant difference in the distribution of blood types in rheumatic diseases. While SpA, vasculitis, UCTD, Behçet's and RA were more common in the patients with A blood type; FMF, SLE, SSc and SjS were more common in the patients with O blood type. In addition, the blood type where all the diseases are observed the least commonly was AB. There was significant difference in the distribution of Rh factor in rheumatic diseases. 92.2% patients were Rh positive and 7.8% patients were Rh negative. CONCLUSION: In our study, we thought that the higher incidence of different rheumatic diseases in different blood types was associated with different genetic predisposition.
OBJECTIVE: Various genetic and environmental risk factors have been shown to be associated with the incidence of rheumatic diseases. However, the pathogenesis of rheumatic diseases poorly understood. Several studies have shown associations of ABO blood groups with various diseases. Our study aimed to determine whether there is an association between the types of rheumatic diseases and ABO and Rh blood groups. MATERIAL AND METHODS: The study included the patients, followed up at the Immunology-Rheumatology clinic between January 2016 and December 2016 for diagnosis of rheumatic disease, who had an ABO Rh blood data. Age, gender, type of rheumatic disease, ABO Rh blood groups were recorded. RESULTS: When 823 patients were assessed for blood types, 42.5% patients had A type, 33.2% had O type, 15.4% had B type, and 8.9% had AB type. There was significant difference in the distribution of blood types in rheumatic diseases. While SpA, vasculitis, UCTD, Behçet's and RA were more common in the patients with A blood type; FMF, SLE, SSc and SjS were more common in the patients with O blood type. In addition, the blood type where all the diseases are observed the least commonly was AB. There was significant difference in the distribution of Rh factor in rheumatic diseases. 92.2% patients were Rh positive and 7.8% patients were Rh negative. CONCLUSION: In our study, we thought that the higher incidence of different rheumatic diseases in different blood types was associated with different genetic predisposition.
Authors: Timothy R D J Radstake; Olga Gorlova; Blanca Rueda; Jose-Ezequiel Martin; Behrooz Z Alizadeh; Rogelio Palomino-Morales; Marieke J Coenen; Madelon C Vonk; Alexandre E Voskuyl; Annemie J Schuerwegh; Jasper C Broen; Piet L C M van Riel; Ruben van 't Slot; Annet Italiaander; Roel A Ophoff; Gabriela Riemekasten; Nico Hunzelmann; Carmen P Simeon; Norberto Ortego-Centeno; Miguel A González-Gay; María F González-Escribano; Paolo Airo; Jaap van Laar; Ariane Herrick; Jane Worthington; Roger Hesselstrand; Vanessa Smith; Filip de Keyser; Fredric Houssiau; Meng May Chee; Rajan Madhok; Paul Shiels; Rene Westhovens; Alexander Kreuter; Hans Kiener; Elfride de Baere; Torsten Witte; Leonid Padykov; Lars Klareskog; Lorenzo Beretta; Rafaella Scorza; Benedicte A Lie; Anna-Maria Hoffmann-Vold; Patricia Carreira; John Varga; Monique Hinchcliff; Peter K Gregersen; Annette T Lee; Jun Ying; Younghun Han; Shih-Feng Weng; Christopher I Amos; Fredrick M Wigley; Laura Hummers; J Lee Nelson; Sandeep K Agarwal; Shervin Assassi; Pravitt Gourh; Filemon K Tan; Bobby P C Koeleman; Frank C Arnett; Javier Martin; Maureen D Mayes Journal: Nat Genet Date: 2010-04-11 Impact factor: 38.330
Authors: U Musabak; A Sengul; C Oktenli; S Pay; Z Yesilova; L Kenar; S Y Sanisoglu; A Inal; A Tuzun; A Erdil; S Bagci Journal: Clin Exp Immunol Date: 2004-12 Impact factor: 4.330
Authors: Soumya Raychaudhuri; Cynthia Sandor; Eli A Stahl; Jan Freudenberg; Hye-Soon Lee; Xiaoming Jia; Lars Alfredsson; Leonid Padyukov; Lars Klareskog; Jane Worthington; Katherine A Siminovitch; Sang-Cheol Bae; Robert M Plenge; Peter K Gregersen; Paul I W de Bakker Journal: Nat Genet Date: 2012-01-29 Impact factor: 38.330