Literature DB >> 29307842

Absolute sizing and label-free identification of extracellular vesicles by flow cytometry.

Edwin van der Pol1, Leonie de Rond2, Frank A W Coumans2, Elmar L Gool2, Anita N Böing3, Auguste Sturk3, Rienk Nieuwland3, Ton G van Leeuwen4.   

Abstract

Blood contains extracellular vesicles (EVs), which are biological nanoparticles with clinical applications. In blood plasma, EVs are outnumbered by similar-sized lipoprotein particles (LPs), leading to controversial data such as non-specific binding of antibodies to LPs. Flow cytometry is a clinically applicable technique to characterize single EVs in body fluids. However, flow cytometry data have arbitrary units, impeding standardization, data comparison, and data interpretation, such as differentiation between EVs and LPs. Here we present a new method, named flow cytometry scatter ratio (Flow-SR), to relate the ambiguous light scattering signals of flow cytometry to the diameter and refractive index (RI) of single nanoparticles between 200-500 nm in diameter. Flow-SR enables label-free differentiation between EVs and LPs and improves data interpretation and comparison. Because Flow-SR is easy to implement, widely applicable, and more accurate and faster than existing techniques to size nanoparticles in suspension, Flow-SR has numerous applications in nanomedicine.
Copyright © 2018 The Author. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Drug delivery; exosomes; extracellular vesicles; flow cytometry; nanomedicine; nanoparticles

Mesh：

Substances：

Year:  2018        PMID： 29307842     DOI： 10.1016/j.nano.2017.12.012

Source DB:  PubMed          Journal:  Nanomedicine        ISSN： 1549-9634            Impact factor:   5.307


  36 in total

Review 1.  Recent Advances in Experimental Models of Breast Cancer Exosome Secretion, Characterization and Function.

Authors:  Fanny A Pelissier Vatter; Serena Lucotti; Haiying Zhang
Journal:  J Mammary Gland Biol Neoplasia       Date:  2020-12-22       Impact factor: 2.673

Review 2.  Extracellular vesicles in cardiovascular homeostasis and disease.

Authors:  Joshua D Hutcheson; Elena Aikawa
Journal:  Curr Opin Cardiol       Date:  2018-05       Impact factor: 2.161

Review 3.  Modern Techniques for the Isolation of Extracellular Vesicles and Viruses.

Authors:  Ryan P McNamara; Dirk P Dittmer
Journal:  J Neuroimmune Pharmacol       Date:  2019-09-12       Impact factor: 4.147

4.  The effect of ionising radiation on the phenotype of bone marrow-derived extracellular vesicles.

Authors:  Dávid Kis; Eszter Persa; Tünde Szatmári; Lilla Antal; Attila Bóta; Ilona Barbara Csordás; Rita Hargitai; Bálint Jezsó; Enikő Kis; Judith Mihály; Géza Sáfrány; Zoltán Varga; Katalin Lumniczky
Journal:  Br J Radiol       Date:  2020-09-30       Impact factor: 3.039

5.  Ticagrelor attenuates the increase of extracellular vesicle concentrations in plasma after acute myocardial infarction compared to clopidogrel.

Authors:  Aleksandra Gasecka; Rienk Nieuwland; Monika Budnik; Françoise Dignat-George; Ceren Eyileten; Paul Harrison; Romaric Lacroix; Aurélie Leroyer; Grzegorz Opolski; Kinga Pluta; Edwin van der Pol; Marek Postuła; Pia Siljander; Jolanta M Siller-Matula; Krzysztof J Filipiak
Journal:  J Thromb Haemost       Date:  2020-01-09       Impact factor: 5.824

6.  A simple, high-throughput method of protein and label removal from extracellular vesicle samples.

Authors:  Joshua A Welsh; Bryce Killingsworth; Julia Kepley; Tim Traynor; Kathy McKinnon; Jason Savage; Deven Appel; Kenneth Aldape; Kevin Camphausen; Jay A Berzofsky; Alexander R Ivanov; Ionita H Ghiran; Jennifer C Jones
Journal:  Nanoscale       Date:  2021-02-18       Impact factor: 7.790

7.  FCMPASS Software Aids Extracellular Vesicle Light Scatter Standardization.

Authors:  Joshua A Welsh; Peter Horak; James S Wilkinson; Verity J Ford; Jennifer C Jones; David Smith; Judith A Holloway; Nicola A Englyst
Journal:  Cytometry A       Date:  2019-06-28       Impact factor: 4.714

8.  Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:  Andrea Cossarizza; Hyun-Dong Chang; Andreas Radbruch; Andreas Acs; Dieter Adam; Sabine Adam-Klages; William W Agace; Nima Aghaeepour; Mübeccel Akdis; Matthieu Allez; Larissa Nogueira Almeida; Giorgia Alvisi; Graham Anderson; Immanuel Andrä; Francesco Annunziato; Achille Anselmo; Petra Bacher; Cosima T Baldari; Sudipto Bari; Vincenzo Barnaba; Joana Barros-Martins; Luca Battistini; Wolfgang Bauer; Sabine Baumgart; Nicole Baumgarth; Dirk Baumjohann; Bianka Baying; Mary Bebawy; Burkhard Becher; Wolfgang Beisker; Vladimir Benes; Rudi Beyaert; Alfonso Blanco; Dominic A Boardman; Christian Bogdan; Jessica G Borger; Giovanna Borsellino; Philip E Boulais; Jolene A Bradford; Dirk Brenner; Ryan R Brinkman; Anna E S Brooks; Dirk H Busch; Martin Büscher; Timothy P Bushnell; Federica Calzetti; Garth Cameron; Ilenia Cammarata; Xuetao Cao; Susanna L Cardell; Stefano Casola; Marco A Cassatella; Andrea Cavani; Antonio Celada; Lucienne Chatenoud; Pratip K Chattopadhyay; Sue Chow; Eleni Christakou; Luka Čičin-Šain; Mario Clerici; Federico S Colombo; Laura Cook; Anne Cooke; Andrea M Cooper; Alexandra J Corbett; Antonio Cosma; Lorenzo Cosmi; Pierre G Coulie; Ana Cumano; Ljiljana Cvetkovic; Van Duc Dang; Chantip Dang-Heine; Martin S Davey; Derek Davies; Sara De Biasi; Genny Del Zotto; Gelo Victoriano Dela Cruz; Michael Delacher; Silvia Della Bella; Paolo Dellabona; Günnur Deniz; Mark Dessing; James P Di Santo; Andreas Diefenbach; Francesco Dieli; Andreas Dolf; Thomas Dörner; Regine J Dress; Diana Dudziak; Michael Dustin; Charles-Antoine Dutertre; Friederike Ebner; Sidonia B G Eckle; Matthias Edinger; Pascale Eede; Götz R A Ehrhardt; Marcus Eich; Pablo Engel; Britta Engelhardt; Anna Erdei; Charlotte Esser; Bart Everts; Maximilien Evrard; Christine S Falk; Todd A Fehniger; Mar Felipo-Benavent; Helen Ferry; Markus Feuerer; Andrew Filby; Kata Filkor; Simon Fillatreau; Marie Follo; Irmgard Förster; John Foster; Gemma A Foulds; Britta Frehse; Paul S Frenette; Stefan Frischbutter; Wolfgang Fritzsche; 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Alicia Martínez-Romero; Glòria Martrus; Ivana Marventano; Wlodzimierz Maslinski; Giuseppe Matarese; Anna Vittoria Mattioli; Christian Maueröder; Alessio Mazzoni; James McCluskey; Mairi McGrath; Helen M McGuire; Iain B McInnes; Henrik E Mei; Fritz Melchers; Susanne Melzer; Dirk Mielenz; Stephen D Miller; Kingston H G Mills; Hans Minderman; Jenny Mjösberg; Jonni Moore; Barry Moran; Lorenzo Moretta; Tim R Mosmann; Susann Müller; Gabriele Multhoff; Luis Enrique Muñoz; Christian Münz; Toshinori Nakayama; Milena Nasi; Katrin Neumann; Lai Guan Ng; Antonia Niedobitek; Sussan Nourshargh; Gabriel Núñez; José-Enrique O'Connor; Aaron Ochel; Anna Oja; Diana Ordonez; Alberto Orfao; Eva Orlowski-Oliver; Wenjun Ouyang; Annette Oxenius; Raghavendra Palankar; Isabel Panse; Kovit Pattanapanyasat; Malte Paulsen; Dinko Pavlinic; Livius Penter; Pärt Peterson; Christian Peth; Jordi Petriz; Federica Piancone; Winfried F Pickl; Silvia Piconese; Marcello Pinti; A Graham Pockley; Malgorzata Justyna Podolska; Zhiyong Poon; Katharina Pracht; Immo Prinz; Carlo E M Pucillo; Sally A Quataert; Linda Quatrini; Kylie M Quinn; Helena Radbruch; Tim R D J Radstake; Susann Rahmig; Hans-Peter Rahn; Bartek Rajwa; Gevitha Ravichandran; Yotam Raz; Jonathan A Rebhahn; Diether Recktenwald; Dorothea Reimer; Caetano Reis e Sousa; Ester B M Remmerswaal; Lisa Richter; Laura G Rico; Andy Riddell; Aja M Rieger; J Paul Robinson; Chiara Romagnani; Anna Rubartelli; Jürgen Ruland; Armin Saalmüller; Yvan Saeys; Takashi Saito; Shimon Sakaguchi; Francisco Sala-de-Oyanguren; Yvonne Samstag; Sharon Sanderson; Inga Sandrock; Angela Santoni; Ramon Bellmàs Sanz; Marina Saresella; Catherine Sautes-Fridman; Birgit Sawitzki; Linda Schadt; Alexander Scheffold; Hans U Scherer; Matthias Schiemann; Frank A Schildberg; Esther Schimisky; Andreas Schlitzer; Josephine Schlosser; Stephan Schmid; Steffen Schmitt; Kilian Schober; Daniel Schraivogel; Wolfgang Schuh; Thomas Schüler; Reiner Schulte; Axel Ronald Schulz; Sebastian R Schulz; Cristiano Scottá; Daniel Scott-Algara; David P Sester; T Vincent Shankey; Bruno Silva-Santos; Anna Katharina Simon; Katarzyna M Sitnik; Silvano Sozzani; Daniel E Speiser; Josef Spidlen; Anders Stahlberg; Alan M Stall; Natalie Stanley; Regina Stark; Christina Stehle; Tobit Steinmetz; Hannes Stockinger; Yousuke Takahama; Kiyoshi Takeda; Leonard Tan; Attila Tárnok; Gisa Tiegs; Gergely Toldi; Julia Tornack; Elisabetta Traggiai; Mohamed Trebak; Timothy I M Tree; Joe Trotter; John Trowsdale; Maria Tsoumakidou; Henning Ulrich; Sophia Urbanczyk; Willem van de Veen; Maries van den Broek; Edwin van der Pol; Sofie Van Gassen; Gert Van Isterdael; René A W van Lier; Marc Veldhoen; Salvador Vento-Asturias; Paulo Vieira; David Voehringer; Hans-Dieter Volk; Anouk von Borstel; Konrad von Volkmann; Ari Waisman; Rachael V Walker; Paul K Wallace; Sa A Wang; Xin M Wang; Michael D Ward; Kirsten A Ward-Hartstonge; Klaus Warnatz; Gary Warnes; Sarah Warth; Claudia Waskow; James V Watson; Carsten Watzl; Leonie Wegener; Thomas Weisenburger; Annika Wiedemann; Jürgen Wienands; Anneke Wilharm; Robert John Wilkinson; Gerald Willimsky; James B Wing; Rieke Winkelmann; Thomas H Winkler; Oliver F Wirz; Alicia Wong; Peter Wurst; Jennie H M Yang; Juhao Yang; Maria Yazdanbakhsh; Liping Yu; Alice Yue; Hanlin Zhang; Yi Zhao; Susanne Maria Ziegler; Christina Zielinski; Jakob Zimmermann; Arturo Zychlinsky
Journal:  Eur J Immunol       Date:  2019-10       Impact factor: 6.688

Review 9.  The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer.

Authors:  Esther Schwich; Vera Rebmann
Journal:  Front Immunol       Date:  2018-03-26       Impact factor: 7.561

10.  A Systematic Approach to Improve Scatter Sensitivity of a Flow Cytometer for Detection of Extracellular Vesicles.

Authors:  Leonie de Rond; Edwin van der Pol; Paul R Bloemen; Tina Van Den Broeck; Ludo Monheim; Rienk Nieuwland; Ton G van Leeuwen; Frank A W Coumans
Journal:  Cytometry A       Date:  2020-02-04       Impact factor: 4.355
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