Literature DB >> 29307524

Multifunctional capacity and therapeutic potential of lactoferrin.

Luis Moreno-Expósito1, Rebeca Illescas-Montes2, Lucía Melguizo-Rodríguez3, Concepción Ruiz4, Javier Ramos-Torrecillas5, Elvira de Luna-Bertos6.   

Abstract

Lactoferrin (LF) is a glycoprotein with high functional versatility that is found in most body fluids. The objective of this study was to gather and update information on the properties attributed to LF. According to this review, LF is a good immunomodulatory agent that acts on both innate and adaptive immune responses. It possesses antimicrobial activity against parasites, fungi, and viruses and also has regenerative properties at tissue level and anti-carcinogenic activity. All of these properties endow LF with major therapeutic potential of which little advantage has been taken to date.
Copyright © 2018 Elsevier Inc. All rights reserved.

Keywords:  Anticancer activity; Antimicrobial agent; Immunomodulator; Lactoferrin; Tissue regenerator

Mesh:

Substances:

Year:  2018        PMID: 29307524     DOI: 10.1016/j.lfs.2018.01.002

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  16 in total

1.  Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid-derived suppressor cells in mice.

Authors:  Lingyu Wei; Xuemei Zhang; Jia Wang; Qiurong Ye; Xiang Zheng; Qiu Peng; Ying Zheng; Peishan Liu; Xiaoyue Zhang; Zhengshuo Li; Can Liu; Qun Yan; Guiyuan Li; Jian Ma
Journal:  Oncogene       Date:  2019-08-28       Impact factor: 9.867

2.  Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.

Authors:  Sayuri Nakamura-Bencomo; Denisse A Gutierrez; Elisa Robles-Escajeda; Blanca Iglesias-Figueroa; Tania S Siqueiros-Cendón; Edward A Espinoza-Sánchez; Sigifredo Arévalo-Gallegos; Renato J Aguilera; Quintín Rascón-Cruz; Armando Varela-Ramirez
Journal:  Invest New Drugs       Date:  2020-10-16       Impact factor: 3.850

3.  Effects of Metformin Combined with Lactoferrin on Lipid Accumulation and Metabolism in Mice Fed with High-Fat Diet.

Authors:  Qing-Qing Min; Li-Qiang Qin; Zhen-Zhen Sun; Wen-Ting Zuo; Lin Zhao; Jia-Ying Xu
Journal:  Nutrients       Date:  2018-11-02       Impact factor: 5.717

4.  Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.

Authors:  Lorena S Frontera; Sofía Moyano; Gonzalo Quassollo; Adriana Lanfredi-Rangel; Andrea S Rópolo; María C Touz
Journal:  Sci Rep       Date:  2018-12-21       Impact factor: 4.379

5.  Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings.

Authors:  Madalina Icriverzi; Anca Bonciu; Laurentiu Rusen; Livia Elena Sima; Simona Brajnicov; Anisoara Cimpean; Robert W Evans; Valentina Dinca; Anca Roseanu
Journal:  Materials (Basel)       Date:  2019-10-18       Impact factor: 3.623

6.  Lactoferrin Alleviated AFM1-Induced Apoptosis in Intestinal NCM 460 Cells through the Autophagy Pathway.

Authors:  Hongya Wu; Yanan Gao; Songli Li; Xiaoyu Bao; Jiaqi Wang; Nan Zheng
Journal:  Foods       Date:  2021-12-23

7.  Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice.

Authors:  Zhongnan Xiao; Danmin Shen; Ting Lan; Chao Wei; Weihua Wu; Qingyu Sun; Zhaoli Luo; Wen Chen; Yurui Zhang; Liye Hu; Chenguang Zhang; Yamei Wang; Yabin Lu; Peipei Wang; Fei Yang; Qian Li
Journal:  Redox Biol       Date:  2022-02-02       Impact factor: 11.799

Review 8.  Mitochondrial Oxidative Stress-A Causative Factor and Therapeutic Target in Many Diseases.

Authors:  Paweł Kowalczyk; Dorota Sulejczak; Patrycja Kleczkowska; Iwona Bukowska-Ośko; Marzena Kucia; Marta Popiel; Ewa Wietrak; Karol Kramkowski; Karol Wrzosek; Katarzyna Kaczyńska
Journal:  Int J Mol Sci       Date:  2021-12-13       Impact factor: 5.923

Review 9.  Antitumor effects of targeting myeloid-derived suppressive cells.

Authors:  Dong Zeng; Haixia Long; Bo Zhu
Journal:  Transl Cancer Res       Date:  2020-09       Impact factor: 1.241

10.  Inhibition of breast cancer xenografts in a mouse model and the induction of apoptosis in multiple breast cancer cell lines by lactoferricin B peptide.

Authors:  Rizdwan Rahman; Alyssa Danielle Fonseka; Shiang-Chia Sua; Munirah Ahmad; Ramkumar Rajendran; Stephen Ambu; Fabian Davamani; Alan Soo-Beng Khoo; Ebenezer Chitra
Journal:  J Cell Mol Med       Date:  2021-07-08       Impact factor: 5.310

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