Literature DB >> 29307371

DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin.

Vehbi Atahan Toğay1, Tuğba Semerci Sevimli2, Murat Sevimli3, Dilek Aşcı Çelik2, Nurten Özçelik2.   

Abstract

Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Comet assay; Silmarin; Silybum marianum

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Year:  2017        PMID： 29307371     DOI： 10.1016/j.mrgentox.2017.11.002

Source DB:  PubMed          Journal:  Mutat Res Genet Toxicol Environ Mutagen        ISSN： 1383-5718            Impact factor:   2.873


  3 in total

Review 1.  A Critical Review on Role of Available Synthetic Drugs and Phytochemicals in Insulin Resistance Treatment by Targeting PTP1B.

Authors:  Prangya Rath; Anuj Ranjan; Abhishek Chauhan; Naval Kumar Verma; Atul Bhargava; Ram Prasad; Tanu Jindal
Journal:  Appl Biochem Biotechnol       Date:  2022-07-11       Impact factor: 3.094

2.  In Silico and In Vitro Studies of Mycotoxins and Their Cocktails; Their Toxicity and Its Mitigation by Silibinin Pre-Treatment.

Authors:  Van Nguyen Tran; Jitka Viktorova; Katerina Augustynkova; Nikola Jelenova; Simona Dobiasova; Katerina Rehorova; Marie Fenclova; Milena Stranska-Zachariasova; Libor Vitek; Jana Hajslova; Tomas Ruml
Journal:  Toxins (Basel)       Date:  2020-02-28       Impact factor: 4.546

3.  Protective Effects of Silymarin and Silibinin against DNA Damage in Human Blood Cells.

Authors:  Flávio Fernandes Veloso Borges; Carolina Ribeiro E Silva; Wanessa Moreira Goes; Fernanda Ribeiro Godoy; Fernanda Craveiro Franco; Jefferson Hollanda Véras; Elisa Flávia Luiz Cardoso Bailão; Daniela de Melo E Silva; Clever Gomes Cardoso; Aparecido Divino da Cruz; Lee Chen-Chen
Journal:  Biomed Res Int       Date:  2018-10-02       Impact factor: 3.411
  3 in total

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