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Literature DB >> 29307276

Multiproteinopathy, neurodegeneration and old age: a case study.

Julio C Rojas¹, Melanie L Stephens¹, Gil D Rabinovici¹, Joel H Kramer¹, Bruce L Miller¹, William W Seeley¹.

Abstract

A complex spectrum of mixed brain pathologies is common in older people. This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy. Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies.

Entities: Chemical Disease Gene Mutation Species

Keywords: Alzheimer’s disease; corticobasal syndrome; frontotemporal lobar degeneration; multiple proteinopathy; neuropathology

Mesh：

Substances：
tau Proteins

Year: 2018 PMID： 29307276 PMCID： PMC5877460 DOI： 10.1080/13554794.2017.1420199

Source DB: PubMed Journal: Neurocase ISSN： 1355-4794 Impact factor: 0.881

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