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Literature DB >> 29307015

Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.

Maryam Tahvildari^1,2, Afsaneh Amouzegar¹, William Foulsham¹, Reza Dana³.

Abstract

The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.

Entities: Chemical Disease Gene Species

Keywords: Allotolerance; Antigen presenting cells; Corneal hemangiogenesis; Corneal lymphangiogenesis; Corneal transplantation; Graft rejection; Regulatory T cells

Mesh：

Year: 2018 PMID： 29307015 PMCID： PMC5899040 DOI： 10.1007/s00018-017-2739-y

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

122 in total

1. CD4(+) T-cell-mediated mechanisms of corneal allograft rejection: role of Fas-induced apoptosis.

Authors: Sushma Hegde; Clay Beauregard; Elizabeth Mayhew; Jerry Y Niederkorn
Journal: Transplantation Date: 2005-01-15 Impact factor: 4.939

2. Expression of the chemokine antagonist vMIP II using a non-viral vector can prolong corneal allograft survival.

Authors: Radhakrishna G Pillai; Sven C Beutelspacher; D Frank P Larkin; Andrew J T George
Journal: Transplantation Date: 2008-06-15 Impact factor: 4.939

3. Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model.

Authors: Zhe Jia; Chunna Jiao; Shaozhen Zhao; Xiaorong Li; Xinjun Ren; Lei Zhang; Zhong Chao Han; Xiaomin Zhang
Journal: Exp Eye Res Date: 2012-07-16 Impact factor: 3.467

Review 4. Tolerogenic dendritic cells and their role in transplantation.

Authors: Mohamed Ezzelarab; Angus W Thomson
Journal: Semin Immunol Date: 2011-07-07 Impact factor: 11.130

5. Subconjunctival and/or intrastromal bevacizumab injections as preconditioning therapy to promote corneal graft survival.

Authors: Romina Fasciani; Luigi Mosca; Maria Ilaria Giannico; Simone Antonio Ambrogio; Emilio Balestrazzi
Journal: Int Ophthalmol Date: 2014-04-09 Impact factor: 2.031

6. IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts.

Authors: Khrishen Cunnusamy; Peter W Chen; Jerry Y Niederkorn
Journal: J Immunol Date: 2011-05-06 Impact factor: 5.422

Review 7. Corneal antigen-presenting cells.

Authors: Pedram Hamrah; M Reza Dana
Journal: Chem Immunol Allergy Date: 2007

8. Major histocompatibility complex semi-matching improves murine corneal allograft survival under oxidative macrophage dominancy.

Authors: Jun Yamada; Junji Hamuro; Kazuto Terai; Shigeru Kinoshita
Journal: Transplantation Date: 2007-10-15 Impact factor: 4.939

9. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation.

Authors: Maryam Tahvildari; Parisa Emami-Naeini; Masahiro Omoto; Alireza Mashaghi; Sunil K Chauhan; Reza Dana
Journal: Sci Rep Date: 2017-04-20 Impact factor: 4.379

Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.

1. CD4(+) T-cell-mediated mechanisms of corneal allograft rejection: role of Fas-induced apoptosis.

2. Expression of the chemokine antagonist vMIP II using a non-viral vector can prolong corneal allograft survival.

3. Immunomodulatory effects of mesenchymal stem cells in a rat corneal allograft rejection model.

Review 4. Tolerogenic dendritic cells and their role in transplantation.

5. Subconjunctival and/or intrastromal bevacizumab injections as preconditioning therapy to promote corneal graft survival.

6. IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts.

Review 7. Corneal antigen-presenting cells.

8. Major histocompatibility complex semi-matching improves murine corneal allograft survival under oxidative macrophage dominancy.

9. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation.

10. The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking.

Review 1. Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Review 2. Corneal Allografts: Factors for and against Acceptance.

3. Time- and Stimulus-Dependent Characteristics of Innate Immune Cells in Organ-Cultured Human Corneal Tissue.

Review 4. Tolerance Induction in Relation to the Eye.