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Literature DB >> 29306442

Imaging Mycobacterial Trehalose Glycolipids.

Mireille Kamariza¹, Peyton Shieh¹, Carolyn R Bertozzi².

Abstract

Cell surface trehalose mycolates are important modulators of mycobacterial pathogenesis and host immune response. We discuss the use of fluorescent and fluorogenic trehalose probes for the detection of the mycobacterial trehalose glycolipids. These probes enable real-time imaging of trehalose mycolate biosynthesis and mycomembrane dynamics in the laboratory as well as in clinical settings for the detection of mycobacteria in patient samples.

Entities: Chemical

Keywords: Fluorescent dye; Glycolipid imaging; Mycobacterium tuberculosis; Mycolic acids; TB diagnostics; Trehalose; Tuberculosis

Mesh：

Substances：

Year: 2017 PMID： 29306442 PMCID： PMC6038140 DOI： 10.1016/bs.mie.2017.09.002

Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600

28 in total

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Authors: Anna E Grzegorzewicz; Ha Pham; Vijay A K B Gundi; Michael S Scherman; Elton J North; Tamara Hess; Victoria Jones; Veronica Gruppo; Sarah E M Born; Jana Korduláková; Sivagami Sundaram Chavadi; Christophe Morisseau; Anne J Lenaerts; Richard E Lee; Michael R McNeil; Mary Jackson
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