Hideo Nakanishi1, Kenji Suda2, Munemitsu Yoshikawa2, Tadamichi Akagi2, Takanori Kameda2, Hanako Ohashi Ikeda2, Satoshi Yokota2, Yasuo Kurimoto2,3, Akitaka Tsujikawa2. 1. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan. hideon@kuhp.kyoto-u.ac.jp. 2. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto, 606-8507, Japan. 3. Department of Ophthalmology, Kobe City Medical Center General Hospital, Minatojimaminamimachi 2-2-1, Chuo-ku, Kobe-city, Hyogo, 650-0047, Japan.
Abstract
PURPOSE: To examine the morphology of Bruch's membrane opening (BMO), optic disc, and peripapillary atrophy (PPA) by scanning laser ophthalmoscopy (SLO) and spectral-domain optical coherence tomography (SD-OCT), and to determine their association with the axial length and visual field defects. METHODS: This was a cross-sectional study of 94 eyes of 56 subjects; 77 eyes were diagnosed with primary open-angle glaucoma and 17 eyes as normal. The margins of the optic disc were determined in the SLO images, and that of the BMO in the SD-OCT images. The ovality and area of the BMO and the optic disc were measured. The beta and gamma-PPA areas were also measured. The association of each parameter with the axial length and the mean deviation (MD) of the visual field tests was determined by generalized estimating equations (GEEs). RESULTS: The optic disc ovality was associated with the axial length and the MD (β = -0.47, P = 7.6 × 10-4 and β = 0.12, P = 0.040). The BMO ovality was not significantly associated with the axial length and the MD. The BMO area was associated with the axial length (β = 0.30, P = 0.029). A larger BMO area was associated with a thinner BMO-based neuroretinal rim width (BMO-MRW) after adjustments for the MD (β = -0.30, P = 2.1 × 10-4). The beta- and gamma-PPA areas were associated with the axial length (β = 0.50, P = 7.4 × 10-5 and β = 0.62, P = 4.2 × 10-6). CONCLUSIONS: The optic disc ovality was associated with both the axial length and MD, whereas BMO ovality was not. Attention should be paid to the influence of the axial length-related enlargement of the BMO.
PURPOSE: To examine the morphology of Bruch's membrane opening (BMO), optic disc, and peripapillary atrophy (PPA) by scanning laser ophthalmoscopy (SLO) and spectral-domain optical coherence tomography (SD-OCT), and to determine their association with the axial length and visual field defects. METHODS: This was a cross-sectional study of 94 eyes of 56 subjects; 77 eyes were diagnosed with primary open-angle glaucoma and 17 eyes as normal. The margins of the optic disc were determined in the SLO images, and that of the BMO in the SD-OCT images. The ovality and area of the BMO and the optic disc were measured. The beta and gamma-PPA areas were also measured. The association of each parameter with the axial length and the mean deviation (MD) of the visual field tests was determined by generalized estimating equations (GEEs). RESULTS: The optic disc ovality was associated with the axial length and the MD (β = -0.47, P = 7.6 × 10-4 and β = 0.12, P = 0.040). The BMO ovality was not significantly associated with the axial length and the MD. The BMO area was associated with the axial length (β = 0.30, P = 0.029). A larger BMO area was associated with a thinner BMO-based neuroretinal rim width (BMO-MRW) after adjustments for the MD (β = -0.30, P = 2.1 × 10-4). The beta- and gamma-PPA areas were associated with the axial length (β = 0.50, P = 7.4 × 10-5 and β = 0.62, P = 4.2 × 10-6). CONCLUSIONS: The optic disc ovality was associated with both the axial length and MD, whereas BMO ovality was not. Attention should be paid to the influence of the axial length-related enlargement of the BMO.
Authors: Ebenezer Daniel; Victoria Addis; Maureen G Maguire; Brendan McGeehan; Min Chen; Rebecca J Salowe; Selam Zenebe-Gete; Elana Meer; Roy Lee; Eli Smith; Harini V Gudiseva; Prithvi S Sankar; Joan M O'Brien Journal: Ophthalmol Glaucoma Date: 2022-02-10
Authors: Jasmin Rezapour; Christopher Bowd; Jade Dohleman; Akram Belghith; James A Proudfoot; Mark Christopher; Leslie Hyman; Jost B Jonas; Massimo A Fazio; Robert N Weinreb; Linda M Zangwill Journal: Sci Rep Date: 2021-04-23 Impact factor: 4.996
Authors: Jasmin Rezapour; Andrew Q Tran; Christopher Bowd; Nevin W El-Nimri; Akram Belghith; Mark Christopher; Nicole Brye; James A Proudfoot; Jade Dohleman; Massimo A Fazio; Jost B Jonas; Robert N Weinreb; Linda M Zangwill Journal: Front Med (Lausanne) Date: 2022-06-24