Literature DB >> 2930549

Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme A thioesters of hypolipidaemic drugs.

M Bronfman1, A Orellana, M N Morales, F Bieri, F Waechter, W Stäubli, P Bentley.   

Abstract

Acyl-Coenzyme A thioesters of the hypolipidaemic and cancerinogenic peroxisome proliferators clofibric acid, nafenopin, ciprofibrate, bezafibrate and tibric acid were found to greatly increase the activity of rat brain protein kinase C. Maximal activation required the simultaneous presence of Ca+2, phosphatidylserine and diolein, thus differentiating their action from that of other tumor promoters such as phorbol esters. Under similar conditions the unesterified drugs were comparatively ineffective. Similar results were obtained using the rat liver enzyme. The data suggest that acylcoenzyme A thioesters of hypolipidaemic drugs, may play a role in the induction of liver tumors by these compounds, through the potentiation of protein kinase C.

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Year:  1989        PMID： 2930549     DOI： 10.1016/0006-291x(89)92211-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase.

Authors:  L Amigo; M C McElroy; M N Morales; M Bronfman
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

2.  Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.

Authors:  Israr-Ul H Ansari; Melissa J Longacre; Scott W Stoker; Mindy A Kendrick; Lucas M O'Neill; Laura J Zitur; Luis A Fernandez; James M Ntambi; Michael J MacDonald
Journal:  Arch Biochem Biophys       Date:  2017-02-11       Impact factor: 4.013

3.  Hypolipidaemic drugs are activated to acyl-CoA esters in isolated rat hepatocytes. Detection of drug activation by human liver homogenates and by human platelets.

Authors:  M Bronfman; M N Morales; L Amigo; A Orellana; L Nuñez; L Cárdenas; P C Hidalgo
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

4.  Suppression of agonist induced Ca2+ oscillations in cultured hepatocytes by nafenopin: possible involvement of protein kinase C.

Authors:  E Leibold; A Stampfl; L R Schwarz
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

5.  Long-chain fatty Acyl-CoA synthetase enzymatic activity in rat liver cell nuclei.

Authors:  A Ves-Losada; R R Brenner
Journal:  Mol Cell Biochem       Date:  1996-06-07       Impact factor: 3.396

6.  A stationary-phase acyl-coenzyme A synthetase of Streptomyces coelicolor A3(2) is necessary for the normal onset of antibiotic production.

Authors:  C Banchio; H Gramajo
Journal:  Appl Environ Microbiol       Date:  2002-09       Impact factor: 4.792

Review 7.  Mechanisms of regulation of liver fatty acid-binding protein.

Authors:  R M Kaikaus; W K Chan; P R Ortiz de Montellano; N M Bass
Journal:  Mol Cell Biochem       Date:  1993 Jun 9-23       Impact factor: 3.396

8.  Activation of a peroxisome-proliferating catabolite of cholic acid to its CoA ester.

Authors:  T Nishimaki-Mogami; A Takahashi; Y Hayashi
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857

9.  A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.

Authors:  I Longo; S G M Frints; J-P Fryns; I Meloni; C Pescucci; F Ariani; M Borghgraef; M Raynaud; P Marynen; C Schwartz; A Renieri; G Froyen
Journal:  J Med Genet       Date:  2003-01       Impact factor: 6.318
  9 in total

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