Literature DB >> 2930547

Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-beta.

M Iwamoto1, K Sato, K Nakashima, H Fuchihata, F Suzuki, Y Kato.   

Abstract

Fibroblast growth factor (FGF) induces colony formation by chondrocytes in soft agar (Y. Kato et al., J. Cell. Physiol., 1987), and the present study revealed that transforming growth factor-beta(TGF-beta) does not induce the same effect. TGF-beta did, however, increase the efficiency of colony formation by chondrocytes 3- to 4-fold in the presence of a maximal dose of FGF. Furthermore, TGF-beta decreased the concentrations of FGF needed for the induction of cell growth in soft agar by 40- to 100-fold. These results suggest that TGF-beta is involved in the control of cartilage growth possibly by increasing the responsiveness of chondrocytes to FGF.

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Year:  1989        PMID： 2930547     DOI： 10.1016/0006-291x(89)92208-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Transforming growth factor-beta: its effect on phenotype reexpression by dedifferentiated chondrocytes in the presence and absence of osteogenin.

Authors:  E T Harrison; F P Luyten; A H Reddi
Journal:  In Vitro Cell Dev Biol       Date:  1992-06

2.  Effects of transforming growth factor beta s and basic fibroblast growth factor on articular chondrocytes obtained from immobilised rabbit knees.

Authors:  R Okazaki; A Sakai; T Nakamura; N Kunugita; T Norimura; K Suzuki
Journal:  Ann Rheum Dis       Date:  1996-03       Impact factor: 19.103

3.  Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes. Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH.

Authors:  T Koike; M Iwamoto; A Shimazu; K Nakashima; F Suzuki; Y Kato
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

4.  Accelerators of osteogenesis by recombinant human bone morphogenetic protein-2.

Authors:  Yasunori Okubo; Kenji Kusumoto; Kazuhisa Bessho
Journal:  Drug Target Insights       Date:  2007-02-21

5.  Chondromodulin-1 directly suppresses growth of human cancer cells.

Authors:  Hisashi Mera; Hiroyuki Kawashima; Tatsuya Yoshizawa; Osamu Ishibashi; Md Moksed Ali; Tadashi Hayami; Hiroshi Kitahara; Hiroshi Yamagiwa; Naoki Kondo; Akira Ogose; Naoto Endo; Hiroyuki Kawashima
Journal:  BMC Cancer       Date:  2009-05-31       Impact factor: 4.430

6.  Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes.

Authors:  T Takebayashi; M Iwamoto; A Jikko; T Matsumura; M Enomoto-Iwamoto; F Myoukai; E Koyama; T Yamaai; K Matsumoto; T Nakamura
Journal:  J Cell Biol       Date:  1995-06       Impact factor: 10.539
  6 in total

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