Literature DB >> 2930540

Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism.

G S DeCherney1, N Gesundheit, P W Gyves, C R Showalter, B D Weintraub.   

Abstract

We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta subunits. Aging per se had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.

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Year:  1989        PMID： 2930540     DOI： 10.1016/0006-291x(89)90059-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Tissue-specific posttranslational modification allows functional targeting of thyrotropin.

Authors:  Keisuke Ikegami; Xiao-Hui Liao; Yuta Hoshino; Hiroko Ono; Wataru Ota; Yuka Ito; Taeko Nishiwaki-Ohkawa; Chihiro Sato; Ken Kitajima; Masayuki Iigo; Yasufumi Shigeyoshi; Masanobu Yamada; Yoshiharu Murata; Samuel Refetoff; Takashi Yoshimura
Journal:  Cell Rep       Date:  2014-10-30       Impact factor: 9.423

Review 2.  Role of glycosylation in function of follicle-stimulating hormone.

Authors:  A Ulloa-Aguirre; C Timossi; P Damián-Matsumura; J A Dias
Journal:  Endocrine       Date:  1999-12       Impact factor: 3.633

3.  Changes in the sialylation and sulfation of secreted thyrotropin in congenital hypothyroidism.

Authors:  P W Gyves; N Gesundheit; N R Thotakura; B S Stannard; G S DeCherney; B D Weintraub
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

Authors:  L Persani; M Tonacchera; P Beck-Peccoz; P Vitti; C Mammoli; L Chiovato; R Elisei; G Faglia; M Ludgate; G Vassart
Journal:  J Endocrinol Invest       Date:  1993 Jul-Aug       Impact factor: 4.256

Review 5.  Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders.

Authors:  Marta Ząbczyńska; Kamila Kozłowska; Ewa Pocheć
Journal:  Int J Mol Sci       Date:  2018-09-17       Impact factor: 5.923
  5 in total

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