Literature DB >> 29305005

The Composition, Development, and Regeneration of Neuromuscular Junctions.

Wenxuan Liu1, Joe V Chakkalakal2.   

Abstract

The neuromuscular junction (NMJ) is the specialized site that connects the terminal of a motor neuron axon to skeletal muscle. As a synapse NMJ integrity is essential for transducing motor neuron signals that initiate skeletal muscle contraction. Many diseases and skeletal muscle aging are linked to impaired NMJ function and the associated muscle wasting. In this chapter we review the components of an NMJ and, the processes of NMJ development, maturation, and regeneration. Also, we briefly discuss the cellular and molecular mechanisms of NMJ decline in the context of disease and aging.
© 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aging; Congenital myasthenia syndrome; Motor neuron; Myasthenia gravis; Myogenesis; Neuromuscular disorders; Regeneration; Sarcopenia; Satellite cells; Skeletal muscle; Stem cells; Synapse

Mesh：

Year:  2017        PMID： 29305005     DOI： 10.1016/bs.ctdb.2017.08.005

Source DB:  PubMed          Journal:  Curr Top Dev Biol        ISSN： 0070-2153            Impact factor:   4.897


  13 in total

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