Literature DB >> 2930495

Pyruvate carboxylation in the rat heart. Role of biotin-dependent enzymes.

K E Sundqvist1, J K Hiltunen, I E Hassinen.   

Abstract

Pyruvate carboxylation in the isolated perfused rat heart was studied under steady-state conditions. A biotin deficiency resulting in a 90% decrease in myocardial pyruvate carboxylase left the pyruvate carboxylation rate unchanged. Pyruvate carboxylation in heart muscle must therefore take place by means of an enzyme which does not contain biotin. The kinetic properties and mass-action ratio of the NADP-linked malic enzyme in heart muscle can be taken as circumstantial evidence in favour of the role of malic enzyme in pyruvate carboxylation in myocardium.

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Year:  1989        PMID： 2930495      PMCID： PMC1135674          DOI： 10.1042/bj2570913

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

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Journal:  J Biol Chem       Date:  1974-09-10       Impact factor: 5.157

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Authors:  R C Lin; E J Davis
Journal:  J Biol Chem       Date:  1974-06-25       Impact factor: 5.157

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Journal:  Biochem J       Date:  1970-05       Impact factor: 3.857

10.  Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase.

Authors:  J K Hiltunen; I E Hassinen
Journal:  Biochim Biophys Acta       Date:  1976-08-13
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  6 in total

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Authors:  Cheng-Yang Wu; Santhosh Satapati; Wenjun Gui; R Max Wynn; Gaurav Sharma; Mingliang Lou; Xiangbing Qi; Shawn C Burgess; Craig Malloy; Chalermchai Khemtong; A Dean Sherry; David T Chuang; Matthew E Merritt
Journal:  J Biol Chem       Date:  2018-05-08       Impact factor: 5.157

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Authors:  R R Russell; H Taegtmeyer
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808

4.  Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer.

Authors:  Mary Anna Carbone; Brian H Robinson
Journal:  Biochem J       Date:  2003-02-15       Impact factor: 3.857

5.  Barth Syndrome: Exploring Cardiac Metabolism with Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Authors:  Erica M Fatica; Gina A DeLeonibus; Alisha House; Jillian V Kodger; Ryan W Pearce; Rohan R Shah; Liraz Levi; Yana Sandlers
Journal:  Metabolites       Date:  2019-12-17

6.  Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.

Authors:  Kyle S McCommis; Attila Kovacs; Carla J Weinheimer; Trevor M Shew; Timothy R Koves; Olga R Ilkayeva; Dakota R Kamm; Kelly D Pyles; M Todd King; Richard L Veech; Brian J DeBosch; Deborah M Muoio; Richard W Gross; Brian N Finck
Journal:  Nat Metab       Date:  2020-10-26
  6 in total

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