Literature DB >> 2930472

Characteristics of butanol metabolism in alcohol dehydrogenase-deficient deermice.

J A Alderman1, S Kato, C S Lieber.   

Abstract

Deermice lacking the low-Km alcohol dehydrogenase eliminated butan-1-ol, a substrate for microsomal oxidation but not for catalase, at 117 mumol/min per kg body wt. Microsomal fractions and hepatocytes metabolized butan-1-ol also (Vmax. = 6.7 nmol/min per nmol of cytochrome P-450, Km = 0.85 mM; Vmax. = 5.3 nmol/min per 10(6) cells, Km = 0.71 mM respectively). These results are consistent with alcohol oxidation by the microsomal system in these deermice.

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Year:  1989        PMID： 2930472      PMCID： PMC1135624          DOI： 10.1042/bj2570615

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver.

Authors:  N Oshino; D Jamieson; B Chance
Journal:  Biochem J       Date:  1975-01       Impact factor: 3.857

2.  In vivo role of the microsomal ethanol-oxidizing system in ethanol metabolism by deermice lacking alcohol dehydrogenase.

Authors:  S Kato; J Alderman; C S Lieber
Journal:  Biochem Pharmacol       Date:  1988-07-01       Impact factor: 5.858

3.  Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo.

Authors:  C S Lieber; L M DeCarli
Journal:  J Biol Chem       Date:  1970-05-25       Impact factor: 5.157

4.  Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase.

Authors:  K G Burnett; M R Felder
Journal:  Biochem Pharmacol       Date:  1980-02       Impact factor: 5.858

5.  NADPH-dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes.

Authors:  R Teschke; Y Hasumura; C S Lieber
Journal:  Biochem Biophys Res Commun       Date:  1974-09-23       Impact factor: 3.575

6.  Assessment of the role of non-ADH ethanol oxidation in vivo and in hepatocytes from deermice.

Authors:  T Takagi; J Alderman; J Gellert; C S Lieber
Journal:  Biochem Pharmacol       Date:  1986-10-15       Impact factor: 5.858

7.  Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deermice lacking alcohol dehydrogenase (ADH).

Authors:  Y Shigeta; F Nomura; S Iida; M A Leo; M R Felder; C S Lieber
Journal:  Biochem Pharmacol       Date:  1984-03-01       Impact factor: 5.858

8.  Catalase-dependent ethanol metabolism in vivo in deermice lacking alcohol dehydrogenase.

Authors:  J A Handler; B U Bradford; E Glassman; J K Ladine; R G Thurman
Journal:  Biochem Pharmacol       Date:  1986-12-15       Impact factor: 5.858

9.  Respective roles of the microsomal ethanol oxidizing system and catalase in ethanol metabolism by deermice lacking alcohol dehydrogenase.

Authors:  S Kato; J Alderman; C S Lieber
Journal:  Arch Biochem Biophys       Date:  1987-05-01       Impact factor: 4.013

10.  Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

Authors:  E T Morgan; D R Koop; M J Coon
Journal:  J Biol Chem       Date:  1982-12-10       Impact factor: 5.157
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  1 in total

Review 1.  Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System.

Authors:  Martha Lucinda Contreras-Zentella; Daniel Villalobos-García; Rolando Hernández-Muñoz
Journal:  Antioxidants (Basel)       Date:  2022-06-26
  1 in total

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