Teodoro J Oscanoa1, José P Amado2, Roman Romero-Ortuno3, José A Hidalgo4. 1. Centro de Investigación de Seguridad de Medicamentos de la Facultad de Medicina de la Universidad de San Martín de Porres, Internal Medicine Department, Hospital Almenara ESSALUD, Lima. Av. Grau 800, La Victoria, Lima -13, Peru. Electronic address: toscanoae@usmp.pe. 2. Facultad de Medicina de la Universidad Nacional Mayor de San Marcos, Av Grau 755, Distrito de Lima 15001, Lima, Peru. Electronic address: jpamadot@gmail.com. 3. Clinical Gerontology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom. Electronic address: roman.romero-ortuno@nhs.net. 4. Internal Medicine Department, Hospital Almenara ESSALUD, Lima. Av. Grau 800, La Victoria, Lima -13, Peru. Electronic address: pepinhidalgo@yahoo.com.
Abstract
AIM: CKD-EPIcr (Chronic Kidney Disease Epidemiology Collaboration creatinine) and BIS1 (Berlin Initiative Study) are two serum creatinine-based formulae for the estimation of glomerular filtration rate (GFR). However, their comparative accuracy in older people has not been well established. Our aim was to conduct a systematic comparative study of the accuracy of estimation of GFR in older people with these two formulae. METHODS: We conducted a systematic search in Pubmed, EMBASE and Central databases on the validity of the CKD-EPIcr and BIS1 formulae in people aged 60 or more years. The search ranged from 2009 and 2012 for CKD-EPIcr and BIS1, respectively, until May 2017. The validity criterion for comparing the formulae was to have a P30 accuracy level equal to or greater than 80%. RESULTS: Of 1295 identified studies, 16 met our inclusion criteria. Out of 16 studies reporting the accuracy of the CKD-EPIcr formula, only 5 (31.3%) had P30 scores ≥80% (mean P30 was 77.1 ± 7.711 range 55.5-91.7), and out of 9 studies on accuracy using the BIS1 formula, 6 (66.7%) were ≥80% (mean P30 was 83.88 ± 9.37, range 67.0-95.8). CONCLUSION: Our results suggest that for the estimation of the GFR in older people, BIS1 formula may be more accurate than CKD-EPIcr.
AIM: CKD-EPIcr (Chronic Kidney Disease Epidemiology Collaboration creatinine) and BIS1 (Berlin Initiative Study) are two serum creatinine-based formulae for the estimation of glomerular filtration rate (GFR). However, their comparative accuracy in older people has not been well established. Our aim was to conduct a systematic comparative study of the accuracy of estimation of GFR in older people with these two formulae. METHODS: We conducted a systematic search in Pubmed, EMBASE and Central databases on the validity of the CKD-EPIcr and BIS1 formulae in people aged 60 or more years. The search ranged from 2009 and 2012 for CKD-EPIcr and BIS1, respectively, until May 2017. The validity criterion for comparing the formulae was to have a P30 accuracy level equal to or greater than 80%. RESULTS: Of 1295 identified studies, 16 met our inclusion criteria. Out of 16 studies reporting the accuracy of the CKD-EPIcr formula, only 5 (31.3%) had P30 scores ≥80% (mean P30 was 77.1 ± 7.711 range 55.5-91.7), and out of 9 studies on accuracy using the BIS1 formula, 6 (66.7%) were ≥80% (mean P30 was 83.88 ± 9.37, range 67.0-95.8). CONCLUSION: Our results suggest that for the estimation of the GFR in older people, BIS1 formula may be more accurate than CKD-EPIcr.
Authors: Kevan R Polkinghorne; Rory Wolfe; Kim M Jachno; James B Wetmore; Robyn L Woods; John J McNeil; Mark R Nelson; Christopher M Reid; Anne M Murray Journal: Nephrology (Carlton) Date: 2019-05-07 Impact factor: 2.506
Authors: Morten Baltzer Houlind; Kristian Kjær Petersen; Henrik Palm; Lillian Mørch Jørgensen; Mia Aakjær; Lona Louring Christrup; Janne Petersen; Ove Andersen; Charlotte Treldal Journal: Pharmaceuticals (Basel) Date: 2018-09-18