Claudio Babiloni1, Giuseppe Noce2, Alfredo Pennica3, Paolo Onorati4, Paolo Capotosto5, Claudio Del Percio2, Paolo Roma6, Valentina Correr6, Elisa Piccinni6, Ginevra Toma7, Andrea Soricelli8, Francesco Di Campli3, Laura Gianserra3, Lorenzo Ciullini3, Antonio Aceti3, Elisabetta Teti9, Loredana Sarmati9, Gloria Crocetti3, Raffaele Ferri10, Valentina Catania10, Maria Teresa Pascarelli10, Massimo Andreoni9, Stefano Ferracuti6. 1. Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: claudio.babiloni@uniroma1.it. 2. Department of Integrated Imaging, IRCCS SDN, Naples, Italy. 3. Infectious Diseases, Faculty of Medicine and Psychology, University of Rome "La Sapienza", Rome, Italy. 4. Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy. 5. Department of Neuroscience, Imaging and Clinical Sciences, and ITAB-Institute of Advanced Biomedical Technologies "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy. 6. Department of Neurology and Psychiatry, University of Rome "La Sapienza", Rome, Italy. 7. Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy. 8. Department of Integrated Imaging, IRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy. 9. Clinical Infectious Diseases, University of Rome "Tor Vergata", Rome, Italy. 10. Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy.
Abstract
OBJECTIVE: Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). METHODS: EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. RESULTS: Widespread sources of delta (<4 Hz) and alpha (8-12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70-75%). CONCLUSIONS: Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. SIGNIFICANCE: This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
OBJECTIVE: Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). METHODS: EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. RESULTS: Widespread sources of delta (<4 Hz) and alpha (8-12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70-75%). CONCLUSIONS: Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. SIGNIFICANCE: This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
Authors: A Barco; S Orlando; G Stroffolini; V Pirriatore; A Lazzaro; D Vai; G Guastamacchia; G Noce; C Atzori; M Trunfio; S Bonora; G Di Perri; A Calcagno Journal: J Neurovirol Date: 2022-01-19 Impact factor: 2.643