Correction: Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

[This corrects the article DOI: 10.1371/journal.pone.0187168.].

There are errors in Table 3. Some of the arrows are missing in the published table. The publisher apologizes for this error. Please see the corrected Table 3 here.

Table 3

Phosphoproteins with different phosphopeptide abundance in the Cyp46a1 brain as compared to the wild type brain.

Abnormal Spatial LearningADD2 (↓)AMPH (↓)ATP1A2 (↑)CTNND2 (↓)HCN1 (↓)MAPT (↓)NCAM1 (↓)PRKCG (↓)SHANK2 (↓)SHANK3 (↓)SLC24A2 (↓)SLC8A2 (↓)Abnormal Long Term Object Recognition MemoryBRAF (↓)CCDC88A (↓)MAPT (↓)SHANK3 (↓)Abnormal Contextual Conditioning BehaviorADD2 (↓)AMPH (↓)CTNND2 (↓)MAP2 (↓)MAPT (↓)PRKCG (↓)

Abnormal Motor LearningHCN1 (↓)MAPT (↓)SHANK3 (↓)SLC24A2 (↓)Reduced Long Term PotentiationADD2 (↓)CCDC88A (↓)CTNNB1 (↑)MAPT (↓)PRKCG (↓)SHANK2 (↓)SHANK3 (↓)SLC24A2 (↓)Abnormal Long Term DepressionSHANK3 (↓)SLC24A2 (↓)SLC8A2 (↓)Abnormal Cerebellum MorphologyATP2B2 (↓)CIT (↓)MAP1B (↑↓)MYO5A (↓)NCAM1 (↓)

Impaired Ability to Fire Action PotentialsKCNA2 (↓)KCNMA1 (↓)MADD (↑)Increased Synaptic DepressionKCNMA1 (↓)SYN1 (↓)SYT1 (↑)Abnormal Neuron PhysiologyHCN2 (↓)KCNQ2 (↓)SHANK3 (↓)SLC8A2 (↓)SYT1 (↑)Abnormal Axon MorphologyANK2 (↓)DST (↓)GAP43 (↓)MAP1B (↑↓)MAPT (↓)NEFH (↑)PLEC (↓)

Abnormal Neurotransmitter SecretionSTXBP1 (↓)SYN1 (↓)SYT1 (↑)Abnormal Synaptic Vesicle NumberBSN (↓)DNAJC6 (↓)KIF1A (↓)MADD (↑)MAP6 (↓)PCDH17 (↓)Abnormal Synaptic Vesicle RecyclingAMPH (↓)DNAJC6 (↓)SYN1 (↓)Abnormal Excitatory Postsynaptic CurrentsCCDC88A (↓)MADD (↑)PRKCG (↓)SHANK3 (↓)SLC1A3 (↓)SYT1 (↑)

Abnormal Synaptic Vesicle ClusteringCTNNB1 (↑)KIF1A (↓)SYN1 (↓)Abnormal Synaptic TransmissionBSN (↓)SHANK3 (↓)STXBP1 (↓)SYT1 (↑)Abnormal Nervous System ElectrophysiologyATP1A2 (↑)HCN1 (↓)HCN2 (↓)KCNA2 (↓)PLCL1 (↓)Axon DegenerationDST (↓)KIF1A (↓)NEFH (↑)STXBP1 (↓)

Phosphoproteins were grouped by the GeneAnalytics (LifeMap Sciences) software and are shown based on involvement in brain processes pertinent to cognition.

↑ or ↓ indicate an increase or decrease, respectively, in the phosphopeptide abundance.

Proteins in bold are those with 2 or more phosphopeptides with differential abundance in the Cyp46a1 brain as compared to the wild type brain.