Ben Gelbart1, Renata DeMarco1, Alexander David Hussey2, Siva P Namachivayam3, Rosemary McRae1, Catherine Quinlan1,4,5, Trevor Duke6. 1. Royal Children's Hospital, Parkville, Victoria, Australia. 2. Pediatric Intensive Care, Starship Children's Hospital, Auckland, New Zealand. 3. Murdoch Children's Research Institute, University of Melbourne, Paediatric Royal Children's Hospital, Parkville, Victoria, Australia. 4. Murdoch Children's Research Institute, Victoria, Australia. 5. University of Melbourne, Victoria, Australia. 6. General Intensive Care Unit, Royal Children's Hospital, Centre for International Child Health, University of Melbourne and MCRI, Victoria, Australia.
Abstract
OBJECTIVES: Rhabdomyolysis is a disorder of muscle breakdown. The aim of this study was to describe the epidemiology of rhabdomyolysis in children admitted to a PICU and to assess the relationship between peak creatinine kinase and mortality. DESIGN: Retrospective cohort study in children admitted to the PICU with rhabdomyolysis between January 1, 2005, and December 31, 2014. Demographic, clinical, and outcome data were recorded. Outcomes were analyzed by level of peak creatinine kinase value (0-10,000, 10,001-50,000, > 50,000IU/L). Long-term renal outcomes were reported for PICU survivors. SETTING: A single-centre academic tertiary PICU. PATIENTS: Children admitted to the PICU with serum creatinine kinase level greater than 1,000 IU/L. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: There were 182 children with rhabdomyolysis. The median peak creatinine kinase value was 3,583 IU/L (1,554-9,608). The primary diagnostic categories included sepsis, trauma, and cardiac arrest. Mortality for peak creatinine kinase values 0-10,000, 10,001-50,000, and > 50,000 IU/L were 24/138 (17%), 6/28 (21%), and 3/16 (19%), respectively (p = 0.87). Children with a peak creatinine kinase greater than 10,000 IU/L had a longer duration of mechanical ventilation and ICU length of stay than children with peak creatinine kinase less than 10,000. Renal replacement therapy was administered in 29/182 (16%). There was longer duration of mechanical ventilation (273 [141-548] vs. 73 [17-206] hr [p < 0.001]) and ICU length of stay (334 [147-618] vs. 100 [37-232] hr (p < 0.001)] in children receiving renal replacement therapy. Continuous veno-venous hemofiltration was the most common modality 23/29 (79%). Only one child required renal replacement therapy postintensive care stay, and adverse long-term renal outcomes were uncommon. CONCLUSIONS: In children with rhabdomyolysis requiring intensive care, peak creatinine kinase was not associated with mortality but is associated with greater use of intensive care resources. Chronic kidney disease is an uncommon sequelae of rhabdomyolysis in children requiring intensive care.
OBJECTIVES:Rhabdomyolysis is a disorder of muscle breakdown. The aim of this study was to describe the epidemiology of rhabdomyolysis in children admitted to a PICU and to assess the relationship between peak creatinine kinase and mortality. DESIGN: Retrospective cohort study in children admitted to the PICU with rhabdomyolysis between January 1, 2005, and December 31, 2014. Demographic, clinical, and outcome data were recorded. Outcomes were analyzed by level of peak creatinine kinase value (0-10,000, 10,001-50,000, > 50,000IU/L). Long-term renal outcomes were reported for PICU survivors. SETTING: A single-centre academic tertiary PICU. PATIENTS: Children admitted to the PICU with serum creatinine kinase level greater than 1,000 IU/L. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: There were 182 children with rhabdomyolysis. The median peak creatinine kinase value was 3,583 IU/L (1,554-9,608). The primary diagnostic categories included sepsis, trauma, and cardiac arrest. Mortality for peak creatinine kinase values 0-10,000, 10,001-50,000, and > 50,000 IU/L were 24/138 (17%), 6/28 (21%), and 3/16 (19%), respectively (p = 0.87). Children with a peak creatinine kinase greater than 10,000 IU/L had a longer duration of mechanical ventilation and ICU length of stay than children with peak creatinine kinase less than 10,000. Renal replacement therapy was administered in 29/182 (16%). There was longer duration of mechanical ventilation (273 [141-548] vs. 73 [17-206] hr [p < 0.001]) and ICU length of stay (334 [147-618] vs. 100 [37-232] hr (p < 0.001)] in children receiving renal replacement therapy. Continuous veno-venous hemofiltration was the most common modality 23/29 (79%). Only one child required renal replacement therapy postintensive care stay, and adverse long-term renal outcomes were uncommon. CONCLUSIONS: In children with rhabdomyolysis requiring intensive care, peak creatinine kinase was not associated with mortality but is associated with greater use of intensive care resources. Chronic kidney disease is an uncommon sequelae of rhabdomyolysis in children requiring intensive care.
Authors: Viktoria Amanda Pfeifle; Simone Schreiner; Daniel Trachsel; Stefan Gerhard Holland-Cunz; Johannes Mayr Journal: Medicine (Baltimore) Date: 2019-04 Impact factor: 1.817
Authors: Sukdong Yoo; Min Hyun Cho; Hee Sun Baek; Ji Yeon Song; Hye Sun Lee; Eun Mi Yang; Kee Hwan Yoo; Su Jin Kim; Jae Il Shin; Keum Hwa Lee; Tae-Sun Ha; Kyung Mi Jang; Jung Won Lee; Kee Hyuck Kim; Heeyeon Cho; Mee Jeong Lee; Jin-Soon Suh; Kyoung Hee Han; Hye Sun Hyun; Il-Soo Ha; Hae Il Cheong; Hee Gyung Kang; Mee Kyung Namgoong; Hye-Kyung Cho; Jae-Hyuk Oh; Sang Taek Lee; Kyo Sun Kim; Joo Hoon Lee; Young Seo Park; Seong Heon Kim Journal: Kidney Res Clin Pract Date: 2021-08-17