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Literature DB >> 29303593

Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template.

Zhong Jin¹, Ling Chu¹, Yan-Qiao Chen¹, Jin-Quan Yu¹.

Abstract

An effective pyridine based U-shaped template has been developed to enable a diverse range of meta-C-H functionalizations of phenylacetic acid scaffolds. This new template has extended the reaction scope to cross-coupling with ArBF3K as well as iodination using 1,3-diiodo-5,5-dimethylhydantoin as the iodination reagent.

Entities: Chemical

Year: 2018 PMID： 29303593 DOI： 10.1021/acs.orglett.7b03336

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

7 in total

Review 1. Achieving Site-Selectivity for C-H Activation Processes Based on Distance and Geometry: A Carpenter's Approach.

Authors: Guangrong Meng; Nelson Y S Lam; Erika L Lucas; Tyler G Saint-Denis; Pritha Verma; Nikita Chekshin; Jin-Quan Yu
Journal: J Am Chem Soc Date: 2020-06-05 Impact factor: 15.419

2. From Pd(OAc)₂ to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions.

Authors: Qian Shao; Kevin Wu; Zhe Zhuang; Shaoqun Qian; Jin-Quan Yu
Journal: Acc Chem Res Date: 2020-03-31 Impact factor: 22.384

3. Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses.

Authors: Nelson Y S Lam; Zhoulong Fan; Kevin Wu; Han Seul Park; Su Yong Shim; Daniel A Strassfeld; Jin-Quan Yu
Journal: J Am Chem Soc Date: 2022-02-02 Impact factor: 16.383

7. Regiocontrol in the oxidative Heck reaction of indole by ligand-enabled switch of the regioselectivity-determining step.

Authors: Yu-Jie Wang; Chen-Hui Yuan; De-Zhao Chu; Lei Jiao
Journal: Chem Sci Date: 2020-09-23 Impact factor: 9.825

7 in total

Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template.

Review 1. Achieving Site-Selectivity for C-H Activation Processes Based on Distance and Geometry: A Carpenter's Approach.

2. From Pd(OAc)₂ to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions.

3. Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses.

4. Rhodium catalyzed template-assisted distal para-C-H olefination.

Review 5. Traditional and sustainable approaches for the construction of C-C bonds by harnessing C-H arylation.

6. Pd(ii)-catalyzed meta-C-H bromination and chlorination of aniline and benzoic acid derivatives.

7. Regiocontrol in the oxidative Heck reaction of indole by ligand-enabled switch of the regioselectivity-determining step.

Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template.

Review 1. Achieving Site-Selectivity for C-H Activation Processes Based on Distance and Geometry: A Carpenter's Approach.

2. From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions.

3. Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses.

4. Rhodium catalyzed template-assisted distal para-C-H olefination.

Review 5. Traditional and sustainable approaches for the construction of C-C bonds by harnessing C-H arylation.

6. Pd(ii)-catalyzed meta-C-H bromination and chlorination of aniline and benzoic acid derivatives.

7. Regiocontrol in the oxidative Heck reaction of indole by ligand-enabled switch of the regioselectivity-determining step.

2. From Pd(OAc)₂ to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions.