| Literature DB >> 29302966 |
Zhiguo Zhang1,2, Dan Zheng1, Yameng Wan1, Guisheng Zhang1, Jingjing Bi1, Qingfeng Liu1, Tongxin Liu1, Lei Shi1.
Abstract
A highly selective, IBX-promoted reaction has been developed for the oxidative cleavage of inert C(aryl)-N bonds on secondary amides while leaving the C(carbonyl)-N bond unchanged. This metal-free reaction proceeds under mild conditions (HFIP/H2O, 25 °C), providing facile access to various useful primary amides, some of which would be otherwise unattainable using conventional aminolysis and hydrolysis approaches.Entities:
Year: 2018 PMID： 29302966 DOI： 10.1021/acs.joc.7b02880
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354