Literature DB >> 2930277

Presence of glycosaminoglycans in purified AA type amyloid fibrils associated with juvenile rheumatoid arthritis.

J H Magnus1, G Husby, S O Kolset.   

Abstract

Previous studies have strongly suggested an association between glycosaminoglycans and tissue deposits of amyloid. The present study was aimed at studying this association in purified preparations of hepatic amyloid fibrils obtained from human AA type secondary amyloidosis. Glycosaminoglycans were isolated by gradient ion exchange chromatography of purified amyloid fibrils treated with pronase. Degradation with specific enzymes identified the glycosaminoglycans as chondroitin sulphate, dermatan sulphate, and heparin/heparan sulphate. The total amount of glycosaminoglycans specifically coisolated with the amyloid fibrils was 15 micrograms/mg fibril weight. The presence of glycosaminoglycans in amyloid may play a part in the incorporation of structurally diverse protein precursors into amyloid fibrils of identical ultrastructure.

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Year:  1989        PMID： 2930277      PMCID： PMC1003724          DOI： 10.1136/ard.48.3.215

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  26 in total

1.  A modified uronic acid carbazole reaction.

Authors:  T BITTER; H M MUIR
Journal:  Anal Biochem       Date:  1962-10       Impact factor: 3.365

2.  The effect of proteoglycans on the morphology of collagen fibrils formed in vitro.

Authors:  K G Vogel; J A Trotter
Journal:  Coll Relat Res       Date:  1987-06

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Authors:  T Bitter; H Muir
Journal:  J Clin Invest       Date:  1966-06       Impact factor: 14.808

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Authors:  G Husby; J B Natvig
Journal:  Clin Exp Immunol       Date:  1972-07       Impact factor: 4.330

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Authors:  G Husby; K Sletten; T E Michaelsen; J B Natvig
Journal:  Scand J Immunol       Date:  1972       Impact factor: 3.487

6.  The association of amyloid P-component (AP) with the amyloid fibril: an updated method for amyloid fibril protein isolation.

Authors:  M Skinner; T Shirahama; A S Cohen; C L Deal
Journal:  Prep Biochem       Date:  1982

7.  Presence and role of glycosaminoglycans in amyloidosis.

Authors:  A Linker; H C Carney
Journal:  Lab Invest       Date:  1987-09       Impact factor: 5.662

8.  Characterization of tissue and plasma glycosaminoglycans during experimental AA amyloidosis and acute inflammation. Qualitative and quantitative analysis.

Authors:  A D Snow; R Kisilevsky; C Stephens; T Anastassiades
Journal:  Lab Invest       Date:  1987-06       Impact factor: 5.662

9.  Transformation of amyloid precursor SAA to protein AA and incorporation in amyloid fibrils in vivo.

Authors:  A Husebekk; B Skogen; G Husby; G Marhaug
Journal:  Scand J Immunol       Date:  1985-03       Impact factor: 3.487

10.  The induction of accelerated murine amyloid with human splenic extract. Probable role of amyloid enhancing factor.

Authors:  J Varga; M S Flinn; T Shirahama; O G Rodgers; A S Cohen
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1986
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  8 in total

Review 1.  Interaction-Induced Structural Transformations in Polysaccharide and Protein-Polysaccharide Gels as Functional Basis for Novel Soft-Matter: A Case of Carrageenans.

Authors:  Olga N Makshakova; Yuriy F Zuev
Journal:  Gels       Date:  2022-05-06

2.  On the association between amyloid fibrils and glycosaminoglycans; possible interactive role of Ca2+ and amyloid P-component.

Authors:  T Stenstad; J H Magnus; K Syse; G Husby
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

3.  A computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formation.

Authors:  Elodie Monsellier; Matteo Ramazzotti; Niccolò Taddei; Fabrizio Chiti
Journal:  PLoS One       Date:  2010-06-29       Impact factor: 3.240

4.  High molecular weight glycosaminoglycans in AA type amyloid fibril extracts from human liver.

Authors:  J H Magnus; S O Kolset; G Husby
Journal:  Ann Rheum Dis       Date:  1991-08       Impact factor: 19.103

5.  Urinary glycosaminoglycans in the course of familial Mediterranean fever.

Authors:  Esra Baskin; Umit Saatçi; Gönenç Ciliv; Aysin Bakkaloglu; Nesrin Besbas; Rezan Topaloglu; Seza Ozen
Journal:  Eur J Pediatr       Date:  2003-03-04       Impact factor: 3.183

6.  Fibronectin and basement membrane components in renal amyloid deposits in patients with primary and secondary amyloidosis.

Authors:  G T Westermark; B Norling; P Westermark
Journal:  Clin Exp Immunol       Date:  1991-10       Impact factor: 4.330

7.  Isolation and characterization of the integral glycosaminoglycan constituents of human amyloid A and monoclonal light-chain amyloid fibrils.

Authors:  S R Nelson; M Lyon; J T Gallagher; E A Johnson; M B Pepys
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

8.  Isolation and partial characterization of heparan sulphate proteoglycans from human hepatic amyloid.

Authors:  J H Magnus; T Stenstad; G Husby; S O Kolset
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857
  8 in total

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