| Literature DB >> 29301655 |
Patrick M Meyer Sauteur1, Ruth Huizinga2, Anne P Tio-Gillen3, Judith Drenthen4, Wendy W J Unger5, Enno Jacobs6, Annemarie M C van Rossum5, Bart C Jacobs7.
Abstract
Mycoplasma pneumoniae (Mp) triggers Guillain-Barré syndrome (GBS) and elicits anti-galactocerebroside (GalC) antibodies. Specifically anti-GalC IgG is associated with Mp-GBS, possibly because of its better ability to cross the blood-nerve barrier (BNB). We here investigated CSF for the presence of anti-GalC in GBS. Intrathecal anti-GalC was found in 46% of Mp-GBS patients (n=6/13), in contrast to 16% of GBS controls (n=4/25) and 0% of non-GBS controls (n=0/7). The antibodies most likely originated from increased BNB permeability and/or intrathecal synthesis. Intrathecal anti-GalC IgG was specifically associated with Mp-GBS, further supporting that anti-GalC IgG contributes to the pathogenesis of GBS.Entities:
Keywords: Cerebrospinal fluid; Galactocerebroside (GalC); Guillain-Barré syndrome (GBS); Intrathecal synthesis; Mycoplasma pneumoniae
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Year: 2017 PMID： 29301655 DOI： 10.1016/j.jneuroim.2017.11.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478