Literature DB >> 29301103

α-Synuclein and Tau: Mitochondrial Kill Switches.

Ulrike Pech1, Patrik Verstreken2.   

Abstract

α-Synuclein resides in Lewy bodies in Parkinson's disease. Ordonez et al. (2017) now show that α-syn disrupts the actin network, causing Drp1-dependent mitochondrial fission defects. This is similar to defects induced by the PD risk factor Tau, suggesting converging pathways in neurodegeneration.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29301103     DOI： 10.1016/j.neuron.2017.12.024

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  3 in total

1.  Alternative Structures of α-Synuclein.

Authors:  Dawid Dułak; Małgorzata Gadzała; Mateusz Banach; Leszek Konieczny; Irena Roterman
Journal:  Molecules       Date:  2020-01-30       Impact factor: 4.411

Review 2.  Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core.

Authors:  Elena Vacchi; Alain Kaelin-Lang; Giorgia Melli
Journal:  Int J Mol Sci       Date:  2020-07-16       Impact factor: 5.923

3.  Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes.

Authors:  Rafael Franco; Juan A Sánchez-Arias; Gemma Navarro; José L Lanciego
Journal:  Front Neuroanat       Date:  2018-06-28       Impact factor: 3.856
  3 in total

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