| Literature DB >> 29299800 |
D G Maldov1, V L Andronova2, S S Grigorian2, E I Isaeva2, P G Deryabin2, D V Mishin2, A A Balakina3, A V Ilyichev4, A A Terentyev3, G A Galegov2.
Abstract
Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V).Entities:
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Year: 2018 PMID： 29299800 DOI： 10.1134/S0012496617060035
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966