| Literature DB >> 29297526 |
Saira F Bakshi1, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei V Tumanov, Craig D Woodworth, Sergiy Minko, Dmitry M Kolpashchikov, Evgeny Katz.
Abstract
A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.Entities:
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Year: 2018 PMID： 29297526 PMCID： PMC5773386 DOI： 10.1039/c7nr08581h
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790