| Literature DB >> 29297493 |
Mark A Rubin1,2,3,4, Francesca Demichelis1,5.
Abstract
With the advent of next-generation sequencing technologies and large whole-exome and genome studies in prostate and other cancers, our understanding of the landscape of genomic alterations has dramatically been refined. In additional to well-known alterations in genomic regions involving 8p, 8q, 10q23, common ETS translocations and androgen receptor amplifications, newer technology have uncovered recurrent mutations in SPOP, FOXA1, MED12, IDH and complex large scale genomic alterations (eg, chromoplexy). This review surveys the enhanced landscape of genomic alterations in clinically localized and advanced prostate cancer.Entities:
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Year: 2018 PMID： 29297493 DOI： 10.1038/modpathol.2017.166
Source DB: PubMed Journal: Mod Pathol ISSN： 0893-3952 Impact factor: 7.842