Literature DB >> 29297120

Expression of focal adhesion genes in mesenchymal stem cells under simulated microgravity.

A Yu Ratushnyy1, L B Buravkova2.   

Abstract

The expression of 84 focal adhesion genes of multipotent mesenchymal stromal cells (MMSCs) after 96-h microgravity simulation at 3D clinorotation was studied. The upregulation of ITGA6, ITGA7, BCAR1, GRB2, CAV1, and DIAPH1 and the downregulation of ITGA11, ITGAV, ITGB1, PTEN, PTK2 (FAK), ARHGAP5, DOCK1, ROCK2, and AKT3 was found. These changes at the transcriptional level may be a cause of the reduction of the osteogenic potential of MMSCs and their ability to migration and adhesion in microgravity.

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Year:  2018        PMID： 29297120     DOI： 10.1134/S1607672917060035

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  13 in total

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4.  [Cytoskeleton structures and adhesion properties of human stromal precursors under conditions of simulated microgravity].

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Review 9.  RhoGTPases as key players in mammalian cell adaptation to microgravity.

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Authors:  Andrey Ratushnyy; Danila Yakubets; Elena Andreeva; Ludmila Buravkova
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Review 3.  The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion.

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5.  Identification of adhesion-associated DNA methylation patterns in the peripheral nervous system.

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Review 6.  Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease.

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  6 in total

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