Literature DB >> 29296783

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S.

José A Fernández1, Xiao Xu1, Ranjeet K Sinha1, Laurent O Mosnier1, Michel F Sanner2, John H Griffin1.   

Abstract

Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.

Entities:  

Year:  2017        PMID： 29296783      PMCID： PMC5727852          DOI： 10.1182/bloodadvances.2017007005

Source DB:  PubMed          Journal:  Blood Adv        ISSN： 2473-9529


  23 in total

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Journal:  J Mol Graph Model       Date:  1999-02       Impact factor: 2.518

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Review 3.  The cytoprotective protein C pathway.

Authors:  Laurent O Mosnier; Berislav V Zlokovic; John H Griffin
Journal:  Blood       Date:  2006-11-16       Impact factor: 22.113

Review 4.  Activated protein C: biased for translation.

Authors:  John H Griffin; Berislav V Zlokovic; Laurent O Mosnier
Journal:  Blood       Date:  2015-03-30       Impact factor: 22.113

5.  Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S.

Authors:  T M Hackeng; S Yegneswaran; A E Johnson; J H Griffin
Journal:  Biochem J       Date:  2000-08-01       Impact factor: 3.857

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Authors:  H P Schwarz; M Fischer; P Hopmeier; M A Batard; J H Griffin
Journal:  Blood       Date:  1984-12       Impact factor: 22.113

8.  Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.

Authors:  Shona Harmon; Roger J S Preston; Fionnuala Ni Ainle; Jennifer A Johnson; Moya S Cunningham; Owen P Smith; Barry White; James S O'Donnell
Journal:  J Biol Chem       Date:  2008-09-08       Impact factor: 5.157

9.  Enhancement of human protein C function by site-directed mutagenesis of the gamma-carboxyglutamic acid domain.

Authors:  L Shen; A M Shah; B Dahlbäck; G L Nelsestuen
Journal:  J Biol Chem       Date:  1998-11-20       Impact factor: 5.157

10.  Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

Authors:  Laurent O Mosnier; Antonella Zampolli; Edward J Kerschen; Reto A Schuepbach; Yajnavalka Banerjee; José A Fernández; Xia V Yang; Matthias Riewald; Hartmut Weiler; Zaverio M Ruggeri; John H Griffin
Journal:  Blood       Date:  2009-02-24       Impact factor: 22.113
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  1 in total

1.  C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities.

Authors:  Atsuki Yamashita; Yuqi Zhang; Michel F Sanner; John H Griffin; Laurent O Mosnier
Journal:  J Thromb Haemost       Date:  2020-03-05       Impact factor: 5.824
  1 in total

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