| Literature DB >> 29296506 |
Jinge Yang1,2, Dan Wu1,2, Guang Zhang1,2, Yuan Zhao1,2, Max Jiang3, Xin Yang1, Qiwen Xu1, Huabei Jiang1,2,4.
Abstract
In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models.Entities:
Keywords: (110.5120) Photoacoustic imaging; (170.2655) Functional monitoring and imaging
Year: 2017 PMID: 29296506 PMCID: PMC5745121 DOI: 10.1364/BOE.8.005814
Source DB: PubMed Journal: Biomed Opt Express ISSN: 2156-7085 Impact factor: 3.732