Literature DB >> 29296506

Intracerebral haemorrhage-induced injury progression assessed by cross-sectional photoacoustic tomography.

Jinge Yang1,2, Dan Wu1,2, Guang Zhang1,2, Yuan Zhao1,2, Max Jiang3, Xin Yang1, Qiwen Xu1, Huabei Jiang1,2,4.   

Abstract

In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models.

Entities:  

Keywords:  (110.5120) Photoacoustic imaging; (170.2655) Functional monitoring and imaging

Year:  2017        PMID: 29296506      PMCID: PMC5745121          DOI: 10.1364/BOE.8.005814

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN: 2156-7085            Impact factor:   3.732


  29 in total

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Review 8.  Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis.

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10.  European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage.

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