| Literature DB >> 29295794 |
Suvarna H Pagire1, Eunhye Lee2, Haushabhau S Pagire1, Eun Jung Bae1, Soo Jung Ryu1, Dahye Lee1, Min Hee Kim1, Geum Ran Kim3, Kyu-Seok Hwang3, Sukyung Ahn2, Jin Hee Maeng2, Jin Sook Song3, Myung Ae Bae3, Don Hang Lee2, Jin Hee Ahn4.
Abstract
A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.Entities:
Keywords: Antioxidant; Glutamic acid derivatives; Ramalin
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Year: 2017 PMID： 29295794 DOI： 10.1016/j.bmcl.2017.11.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823