Jairo Alberto Dussán-Sarria1,2, Nadia Regina Jardim da Silva1,2, Alicia Deitos1,2, Luciana Cadore Stefani1,2,3, Gabriela Laste1,2, Andressa de Souza2,4, Iraci L S Torres1,5, Felipe Fregni6, Wolnei Caumo1,2,3,7. 1. Postgraduation Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. 2. Laboratory of Pain and Neuromodulation, Hospital de Clínicas de Porto Alegre (HCPA)/UFRGS, Porto Alegre, RS, Brazil. 3. Surgery Department, School of Medicine, HCPA/UFRGS, RS, Brazil. 4. La Salle University, Canoas, RS, Brazil. 5. Pharmacology Department, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil. 6. Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, Boston, Massachusetts, USA. 7. Pain and Palliative Care Service at HCPA, Porto Alegre, RS, Brazil.
Abstract
Background: Although the brain-derived neurotrophic factor (BDNF) has been intensively investigated in animal models of chronic pain, its role in human pain processing is less understood. Objective: To study the neurophysiology of BDNF modulation on acute experimental pain, we performed a cross-sectional study. Methods: We recruited 20 healthy male volunteers (19-40 years old) and assessed their serum BDNF levels, quantitative sensory testing, and cortical excitability parameters using transcranial magnetic stimulation. Results: Linear regression models demonstrated that the BDNF (β = -5.245, P = 0.034) and intracortical facilitation (β = -3.311, P = 0.034) were inversely correlated with heat pain threshold (adjusted R2 = 44.26). The BDNF (β = -3.719, P ≤ 0.001) was also inversely correlated with conditioned pain modulation (adjusted R2 = 56.8). Conclusions: Our findings indicate that higher serum BDNF and intracortical facilitation of the primary motor cortex are associated with increased sensitivity to heat pain and high serum BDNF with reduced pain inhibition during noxious heterotopic stimulation.
Background: Although the brain-derived neurotrophic factor (BDNF) has been intensively investigated in animal models of chronic pain, its role in humanpain processing is less understood. Objective: To study the neurophysiology of BDNF modulation on acute experimental pain, we performed a cross-sectional study. Methods: We recruited 20 healthy male volunteers (19-40 years old) and assessed their serum BDNF levels, quantitative sensory testing, and cortical excitability parameters using transcranial magnetic stimulation. Results: Linear regression models demonstrated that the BDNF (β = -5.245, P = 0.034) and intracortical facilitation (β = -3.311, P = 0.034) were inversely correlated with heat pain threshold (adjusted R2 = 44.26). The BDNF (β = -3.719, P ≤ 0.001) was also inversely correlated with conditioned pain modulation (adjusted R2 = 56.8). Conclusions: Our findings indicate that higher serum BDNF and intracortical facilitation of the primary motor cortex are associated with increased sensitivity to heat pain and high serum BDNF with reduced pain inhibition during noxious heterotopic stimulation.
Authors: Setor K Sorkpor; Kelli Galle; Antonio L Teixeira; Gabriela D Colpo; Brian Ahn; Natalie Jackson; Hongyu Miao; Hyochol Ahn Journal: Biol Res Nurs Date: 2021-04-29 Impact factor: 2.318