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Literature DB >> 29293971

Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives.

Nanne K H de Boer¹, Laurent Peyrin-Biroulet², Bindia Jharap³, Jeremy D Sanderson⁴, Berrie Meijer¹, Imke Atreya⁵, Murray L Barclay⁶, Jean-Frederic Colombel⁷, Anthony Lopez², Laurent Beaugerie⁸, Anthony M Marinaki⁹, Adriaan A van Bodegraven^1,10, Markus F Neurath⁵.

Abstract

Thiopurines, available as azathioprine, mercaptopurine, and thioguanine, are immunomodulating agents primarily used to maintain corticosteroid-free remission in patients with inflammatory bowel disease. To provide a state-of-the-art overview of thiopurine treatment in inflammatory bowel disease, this clinical review critically summarises the available literature, as assessed by several experts in the field of thiopurine treatment and research in inflammatory bowel disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2018 PMID： 29293971 DOI： 10.1093/ecco-jcc/jjx181

Source DB: PubMed Journal: J Crohns Colitis ISSN： 1873-9946 Impact factor: 9.071

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Cited

17 in total

1. Higher Mucosal Healing with Tumor Necrosis Factor Inhibitors in Combination with Thiopurines Compared to Methotrexate in Crohn's Disease.

Authors: Abhinav Vasudevan; Ajay Raghunath; Shane Anthony; Cian Scanlon; Miles P Sparrow; Peter R Gibson; Daniel R van Langenberg
Journal: Dig Dis Sci Date: 2018-12-17 Impact factor: 3.199

Review 2. Budding Multi-matrix Technology-a Retrospective Approach, Deep Insights, and Future Perspectives.

Authors: Anitha Sriram; Suma Tangirala; Srividya Atmakuri; Sajid Hoque; Sheela Modani; Saurabh Srivastava; Srushti Mahajan; Indrani Maji; Rahul Kumar; Dharmendra Khatri; Jitender Madan; Pankaj Kumar Singh
Journal: AAPS PharmSciTech Date: 2021-11-03 Impact factor: 3.246

3. Managing IBD in patients with previous cancers.

Authors: Sarah E Minnis-Lyons; Zara Aiken; Shien Chow; Shahida Din
Journal: Frontline Gastroenterol Date: 2022-06-08

Review 4. The Effect of Pregnancy and Inflammatory Bowel Disease on the Pharmacokinetics of Drugs Related to Inflammatory Bowel Disease-A Systematic Literature Review.

Authors: Thomas K Wiersma; Marijn C Visschedijk; Nanne K de Boer; Marjolijn N Lub-de Hooge; Jelmer R Prins; Daan J Touw; Paola Mian
Journal: Pharmaceutics Date: 2022-06-11 Impact factor: 6.525

5. Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.

Authors: Melek Simsek; Debbie S Deben; Carmen S Horjus; Melanie V Bénard; Birgit I Lissenberg-Witte; Hans J C Buiter; Matthijs van Luin; Margien L Seinen; Chris J J Mulder; Dennis R Wong; Nanne K H de Boer; Adriaan A van Bodegraven
Journal: Aliment Pharmacol Ther Date: 2019-05-16 Impact factor: 8.171

6. Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn's disease patients.

Authors: Xia Zhu; Kang Chao; Miao Li; Wen Xie; Hong Zheng; Jin-Xin Zhang; Pin-Jin Hu; Min Huang; Xiang Gao; Xue-Ding Wang
Journal: World J Gastroenterol Date: 2019-10-14 Impact factor: 5.742

Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives.

1. Higher Mucosal Healing with Tumor Necrosis Factor Inhibitors in Combination with Thiopurines Compared to Methotrexate in Crohn's Disease.

Review 2. Budding Multi-matrix Technology-a Retrospective Approach, Deep Insights, and Future Perspectives.

3. Managing IBD in patients with previous cancers.

Review 4. The Effect of Pregnancy and Inflammatory Bowel Disease on the Pharmacokinetics of Drugs Related to Inflammatory Bowel Disease-A Systematic Literature Review.

5. Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.

6. Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn's disease patients.

Review 7. Can We Predict the Toxicity and Response to Thiopurines in Inflammatory Bowel Diseases?

8. Adverse Drug Reactions from Real-World Data in Inflammatory Bowel Disease Patients in the IBDREAM Registry.

9. Gut microbiota-driven drug metabolism in inflammatory bowel disease.

Review 10. Precision medicine in inflammatory bowel disease: concept, progress and challenges.