Literature DB >> 29293352

Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development.

Zachary P Shultz1, Grant A Lawrence1, Jeffrey M Jacobson1, Emmanuel J Cruz1, James W Leahy1,2,3.   

Abstract

A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.

Entities:  

Year:  2018        PMID： 29293352     DOI： 10.1021/acs.orglett.7b03668

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV.

Authors:  Alexandra E Golliher; Antonio J Tenorio; Nina O Dimauro; Nicolas R Mairata; F Omar Holguin; William Maio
Journal:  Tetrahedron Lett       Date:  2021-02-05       Impact factor: 2.415

2.  A cell-free platform for the prenylation of natural products and application to cannabinoid production.

Authors:  Meaghan A Valliere; Tyler P Korman; Nicholas B Woodall; Gregory A Khitrov; Robert E Taylor; David Baker; James U Bowie
Journal:  Nat Commun       Date:  2019-02-04       Impact factor: 14.919

Review 3.  The biosynthesis of the cannabinoids.

Authors:  M Nazir Tahir; Fred Shahbazi; Simon Rondeau-Gagné; John F Trant
Journal:  J Cannabis Res       Date:  2021-03-15
  3 in total

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