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Literature DB >> 29292651

Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model.

Muhammad E Haque¹, Refaat E Gabr², Xiurong Zhao¹, Khader M Hasan², Andrew Valenzuela¹, Ponnada A Narayana², Shun-Ming Ting¹, Guanghua Sun¹, Sean I Savitz¹, Jaroslaw Aronowski¹.

Abstract

Iron released after intracerebral hemorrhage (ICH) is damaging to the brain. Measurement of the content and distribution of iron in the hematoma could predict brain damage. In this study, 16 Yorkshire piglets were subjected to autologous blood injection ICH model and studied longitudinally using quantitative susceptibility mapping and R2* relaxivity MRI on day 1 and 7 post-ICH. Phantom calibration of susceptibility demonstrated (1) iron distribution heterogeneity within the hematoma and (2) natural absorption of iron from 154 ± 78 µg/mL (day 1) to 127 ± 33 µg/mL (day 7). R2* in the hematoma decreased at day 7. This method could be adopted for ICH in humans.

Entities: Chemical Disease Species

Keywords: Quantitative susceptibility mapping; R2*; intracerebral hemorrhage; iron quantification; pig intracerebral hemorrhage

Mesh：

Substances：
Iron

Year: 2018 PMID： 29292651 PMCID： PMC5851147 DOI： 10.1177/0271678X17751548

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

49 in total

1. Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats.

Authors: Tetsuhiro Hatakeyama; Masanobu Okauchi; Ya Hua; Richard F Keep; Guohua Xi
Journal: Acta Neurochir Suppl Date: 2011

2. Acute hematomas: effects of deoxygenation, hematocrit, and fibrin-clot formation and retraction on T2 shortening.

Authors: R A Clark; A T Watanabe; W G Bradley; J D Roberts
Journal: Radiology Date: 1990-04 Impact factor: 11.105

3. Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients.

Authors: Michael J House; Timothy G St Pierre; Kris V Kowdley; Thomas Montine; James Connor; John Beard; Jose Berger; Narendra Siddaiah; Eric Shankland; Lee-Way Jin
Journal: Magn Reson Med Date: 2007-01 Impact factor: 4.668

4. Iron-related brain damage in patients with intracerebral hemorrhage.

Authors: Natalia Pérez de la Ossa; Tomás Sobrino; Yolanda Silva; Miguel Blanco; Monica Millán; Meritxell Gomis; Jesús Agulla; Pablo Araya; Silvia Reverté; Joaquin Serena; Antoni Dávalos
Journal: Stroke Date: 2010-02-25 Impact factor: 7.914

5. Spontaneous intracerebral hemorrhage in humans: hematoma enlargement, clot lysis, and brain edema.

Authors: G Wu; G Xi; F Huang
Journal: Acta Neurochir Suppl Date: 2006

Review 6. Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.

Authors: Jaroslaw Aronowski; Xiurong Zhao
Journal: Stroke Date: 2011-04-28 Impact factor: 7.914

7. Treatment with the iron chelator, deferoxamine mesylate, alters serum markers of oxidative stress in stroke patients.

Authors: Magdy Selim
Journal: Transl Stroke Res Date: 2009-12-10 Impact factor: 6.829

8. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages.

Authors: Xiurong Zhao; Guanghua Sun; Jie Zhang; Roger Strong; Weitao Song; Nicole Gonzales; James C Grotta; Jaroslaw Aronowski
Journal: Ann Neurol Date: 2007-04 Impact factor: 10.422

9. Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging.

Authors: Weili Zheng; Helen Nichol; Saifeng Liu; Yu-Chung N Cheng; E Mark Haacke
Journal: Neuroimage Date: 2013-04-13 Impact factor: 6.556

10. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Authors: Saravanan S Karuppagounder; Ishraq Alim; Soah J Khim; Megan W Bourassa; Sama F Sleiman; Roseleen John; Cyrille C Thinnes; Tzu-Lan Yeh; Marina Demetriades; Sandra Neitemeier; Dana Cruz; Irina Gazaryan; David W Killilea; Lewis Morgenstern; Guohua Xi; Richard F Keep; Timothy Schallert; Ryan V Tappero; Jian Zhong; Sunghee Cho; Frederick R Maxfield; Theodore R Holman; Carsten Culmsee; Guo-Hua Fong; Yijing Su; Guo-li Ming; Hongjun Song; John W Cave; Christopher J Schofield; Frederick Colbourne; Giovanni Coppola; Rajiv R Ratan
Journal: Sci Transl Med Date: 2016-03-02 Impact factor: 17.956

10 in total

10. Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis.

Authors: Bing Chen; Haoran Wang; Chenglin Lv; Chongdan Mao; Yuguang Cui
Journal: Bioengineered Date: 2021-12 Impact factor: 3.269

10 in total

Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model.

1. Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats.

2. Acute hematomas: effects of deoxygenation, hematocrit, and fibrin-clot formation and retraction on T2 shortening.

3. Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients.

4. Iron-related brain damage in patients with intracerebral hemorrhage.

5. Spontaneous intracerebral hemorrhage in humans: hematoma enlargement, clot lysis, and brain edema.

Review 6. Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.

7. Treatment with the iron chelator, deferoxamine mesylate, alters serum markers of oxidative stress in stroke patients.

8. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages.

9. Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging.

10. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

1. Complement Inhibition Attenuates Early Erythrolysis in the Hematoma and Brain Injury in Aged Rats.

2. Quality and validity of large animal experiments in stroke: A systematic review.

3. Perihematomal brain tissue iron concentration measurement by MRI in patients with intracerebral hemorrhage.

Review 4. Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage.

5. Longitudinal, Quantitative, Multimodal MRI Evaluation of Patients With Intracerebral Hemorrhage Over the First Year.

6. Electroacupuncture Reduces Cerebral Hemorrhage Injury in Rats by Improving Cerebral Iron Metabolism.

7. Hemorrhagic stroke-Pathomechanisms of injury and therapeutic options.

8. Serial Metabolic Evaluation of Perihematomal Tissues in the Intracerebral Hemorrhage Pig Model.

Review 9. Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation.

10. Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis.