Yingchao Yin1, Ruipeng Zhang2, Shilun Li3, Jialiang Guo4, Zhiyong Hou5, Yingze Zhang6. 1. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: dryingchao@gmail.com. 2. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: zhangruipengdoctor@126.com. 3. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: lshilun@163.com. 4. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: guojialiang11123@163.com. 5. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: drzyhou@gmail.com. 6. Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Key Laboratory of Biomechanics of Hebei Province, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei Province, China. Electronic address: dr_yzzhang@126.com.
Abstract
OBJECTIVE: To compare the clinical outcomes of negative-pressure wound therapy (NPWT) versus conventional therapy on split-thickness skin after grafting surgery. DESIGN: Meta-analysis. BACKGROUND: Split-thickness skin grafts are widely used in reconstruction of large skin defects. Conventional therapy causes pain during dressing changing. NPWT is an alternative method to cover the wound bed. METHODS: The Pubmed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) or cohort studies for articles published between 1993 and April 2017 comparing NPWT to conventional wound therapy for split-thickness skin grafts. The rate of graft take was the primary outcome of this meta-analysis. Wound infection and reoperation rate of the wound were secondary outcomes. Data analysis was conducted using the Review Manager 5.3 software. RESULTS: Five cohort studies and seven RCTs including 653 patients were eligible for inclusion. Patients treated with NPWT had a significantly higher rate of graft take compared to those treated with conventional therapy [MD = 7.02, (95% CI 3.74, 10.31)] (P = .00). NPWT was associated with a reduction in reoperation [RR = 0.28, (95% CI 0.14, 0.55)] (P = .00). The reduction in wound infection was not significant [RR = 0.63, (95% CI 0.31, 1.27)] (P = .20). CONCLUSION: Compared with conventional therapy, NPWT significantly increases the rate of graft take and reduces the rate of reoperation when applied to cover the wound bed with split-thickness skin graft. No significant impact on wound infection was found in this study.
OBJECTIVE: To compare the clinical outcomes of negative-pressure wound therapy (NPWT) versus conventional therapy on split-thickness skin after grafting surgery. DESIGN: Meta-analysis. BACKGROUND: Split-thickness skin grafts are widely used in reconstruction of large skin defects. Conventional therapy causes pain during dressing changing. NPWT is an alternative method to cover the wound bed. METHODS: The Pubmed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) or cohort studies for articles published between 1993 and April 2017 comparing NPWT to conventional wound therapy for split-thickness skin grafts. The rate of graft take was the primary outcome of this meta-analysis. Wound infection and reoperation rate of the wound were secondary outcomes. Data analysis was conducted using the Review Manager 5.3 software. RESULTS: Five cohort studies and seven RCTs including 653 patients were eligible for inclusion. Patients treated with NPWT had a significantly higher rate of graft take compared to those treated with conventional therapy [MD = 7.02, (95% CI 3.74, 10.31)] (P = .00). NPWT was associated with a reduction in reoperation [RR = 0.28, (95% CI 0.14, 0.55)] (P = .00). The reduction in wound infection was not significant [RR = 0.63, (95% CI 0.31, 1.27)] (P = .20). CONCLUSION: Compared with conventional therapy, NPWT significantly increases the rate of graft take and reduces the rate of reoperation when applied to cover the wound bed with split-thickness skin graft. No significant impact on wound infection was found in this study.
Authors: Yvonne Zens; Michael Barth; Heiner C Bucher; Katrin Dreck; Moritz Felsch; Wolfram Groß; Thomas Jaschinski; Heike Kölsch; Mandy Kromp; Inga Overesch; Stefan Sauerland; Sven Gregor Journal: Syst Rev Date: 2020-10-10
Authors: Joachim N Meuli; Olivier Pantet; Mette M Berger; Laurent Waselle; Wassim Raffoul Journal: J Burn Care Res Date: 2022-01-05 Impact factor: 1.845