Mengwei Ni1, Jeffrey R Kaiser1, Brady S Moffett1, Christopher J Rhee1, Jennifer Placencia1, Kimberly L Dinh1, Joseph L Hagan1, Danielle R Rios1. 1. University of Texas Health Science Center Houston (MN), McGovern Medical School, Houston, Texas, Department of Pediatrics, Section of Neonatology (JRK, CJR, JLH, DRR), Baylor College of Medicine, Houston, Texas, Department of Obstetrics and Gynecology (JRK), Baylor College of Medicine, Houston, Texas, Department of Pharmacy (BSM, JP, KLD), Texas Children's Hospital, Houston, Texas.
Abstract
OBJECTIVE: To evaluate the safety and efficacy of vasopressin for the treatment of hypotension in patients admitted to neonatal intensive care units (NICUs). METHODS: Vasopressin use in 69 infants admitted to our NICU between 2011 and 2014 was examined. Data evaluated included demographics; serum creatinine, sodium, and lactate concentrations; urine output; and systolic, diastolic, and mean blood pressures (BPs). Parameters prior to vasopressin use were compared to those at maximum dose. RESULTS: Vasopressin use was associated with increased urine output (p < 0.05), and increased systolic (p < 0.0005), diastolic (p < 0.01), and mean (p < 0.001) BP. There were no differences in sodium or lactate concentrations before vs during infusion; vasopressin use was not associated with hyponatremia (sodium < 130 mEq/L) at the maximum dose. CONCLUSIONS: Vasopressin for the treatment of neonatal hypotension appears safe and was efficacious in raising BP. These data suggest that vasopressin could be considered a viable option in the treatment regimen in hypotensive infants in the NICU.
OBJECTIVE: To evaluate the safety and efficacy of vasopressin for the treatment of hypotension in patients admitted to neonatal intensive care units (NICUs). METHODS:Vasopressin use in 69 infants admitted to our NICU between 2011 and 2014 was examined. Data evaluated included demographics; serum creatinine, sodium, and lactate concentrations; urine output; and systolic, diastolic, and mean blood pressures (BPs). Parameters prior to vasopressin use were compared to those at maximum dose. RESULTS:Vasopressin use was associated with increased urine output (p < 0.05), and increased systolic (p < 0.0005), diastolic (p < 0.01), and mean (p < 0.001) BP. There were no differences in sodium or lactate concentrations before vs during infusion; vasopressin use was not associated with hyponatremia (sodium < 130 mEq/L) at the maximum dose. CONCLUSIONS:Vasopressin for the treatment of neonatal hypotension appears safe and was efficacious in raising BP. These data suggest that vasopressin could be considered a viable option in the treatment regimen in hypotensiveinfants in the NICU.
Authors: Hans Knotzer; Stephan Maier; Martin W Dünser; Walter R Hasibeder; Hans Hausdorfer; Julia Brandner; Christian Torgersen; Hanno Ulmer; Barbara Friesenecker; Claudia Iannetti; Werner Pajk Journal: Intensive Care Med Date: 2005-11-18 Impact factor: 17.440