Torsten Kraya1, Lena Neumann2, Yvonne Paelecke-Habermann3, Marcus Deschauer4, Dietrich Stoevesandt5, Stephan Zierz2, Stefan Watzke6. 1. Department of Neurology, University of Halle (Saale), Germany. Electronic address: torsten.kraya@medizin.uni-halle.de. 2. Department of Neurology, University of Halle (Saale), Germany. 3. Department of Psychology, University Würzburg, Germany. 4. Department of Neurology, University of Munich, Germany. 5. Department of Radiology, University of Halle (Saale), Germany. 6. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle (Saale), Germany.
Abstract
OBJECTIVE: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. METHODS: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A>G mutation. RESULTS: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. CONCLUSION: Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.
OBJECTIVE: To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. METHODS: Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A>G mutation. RESULTS: The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. CONCLUSION:Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.
Authors: Kim F E van de Loo; Nander T van Zeijl; Mirian C H Janssen; Christianne M Verhaak; José A E Custers Journal: Orphanet J Rare Dis Date: 2022-07-15 Impact factor: 4.303
Authors: Heather L Moore; Thomas Kelly; Alexandra Bright; Robert H Field; Andrew M Schaefer; Alasdair P Blain; Robert W Taylor; Robert McFarland; Doug M Turnbull; Gráinne S Gorman Journal: Ann Clin Transl Neurol Date: 2019-03-27 Impact factor: 4.511