Literature DB >> 29289210

High-speed and low-distortion solution for time-correlated single photon counting measurements: A theoretical analysis.

A Cominelli1, G Acconcia1, P Peronio1, M Ghioni1, I Rech1.   

Abstract

In this paper, we describe a novel solution to increase the speed of Time-Correlated Single Photon Counting (TCSPC) measurements by almost an order of magnitude while providing, in principle, zero distortion regardless of the experimental conditions. Typically, the relatively long dead time associated with the conversion electronics requires a proper tune of the excitation power in order to avoid distortions of the reconstructed waveform due to pileup and counting loss. As a result, the maximum operating rate of a TCSPC channel is now limited between 1% and 5% of the excitation frequency, thus leading to relatively long acquisition times. We show that negligible distortion (below 1%) is guaranteed if the dead time associated with the converter is kept below the dead time of the detector, and at the same time the detector dead time is matched to the duration of the excitation period. In this way, unprecedented high-speed operation is possible. In this paper, we provide a theoretical analysis of the technique, including the main non-idealities which are introduced by a generic physical implementation. The results are supported by both numerical simulations and analytical calculations.

Year:  2017        PMID: 29289210     DOI: 10.1063/1.4996690

Source DB:  PubMed          Journal:  Rev Sci Instrum        ISSN: 0034-6748            Impact factor:   1.523


  3 in total

1.  Probe-hosted large area silicon photomultiplier and high-throughput timing electronics for enhanced performance time-domain functional near-infrared spectroscopy.

Authors:  L Di Sieno; A Behera; S Rohilla; E Ferocino; D Contini; A Torricelli; B Krämer; F Koberling; A Pifferi; A Dalla Mora
Journal:  Biomed Opt Express       Date:  2020-10-16       Impact factor: 3.732

2.  Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications.

Authors:  Rupsa Datta; Tiffany M Heaster; Joe T Sharick; Amani A Gillette; Melissa C Skala
Journal:  J Biomed Opt       Date:  2020-05       Impact factor: 3.170

3.  Effects and correctability of pile-up distortion using established figures of merit in time-domain diffuse optics at extreme photon rates.

Authors:  Elisabetta Avanzi; Anurag Behera; Davide Contini; Lorenzo Spinelli; Alberto Dalla Mora; Laura Di Sieno
Journal:  Sci Rep       Date:  2022-03-30       Impact factor: 4.379

  3 in total

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