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Literature DB >> 29288944

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.

Sujin Park¹, Eun Hye Kim², Jinwoo Kim¹, Seong Hwan Kim³, Ikyon Kim⁴.

Abstract

A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.

Entities: Chemical Disease Species

Keywords: Aldol condensation; Anticancer activity; Chalcone; Hybrid; Indolizine

Mesh：

Substances：

Year: 2017 PMID： 29288944 DOI： 10.1016/j.ejmech.2017.12.056

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

7 in total

1. Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol.

Authors: Arminas Urbonavičius; Graziana Fortunato; Emilija Ambrazaitytė; Elena Plytninkienė; Aurimas Bieliauskas; Vaida Milišiūnaitė; Renzo Luisi; Eglė Arbačiauskienė; Sonata Krikštolaitytė; Algirdas Šačkus
Journal: Molecules Date: 2022-06-10 Impact factor: 4.927

2. Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo.

Authors: Shan Lu; Obinna N Obianom; Yong Ai
Journal: Medchemcomm Date: 2018-08-27 Impact factor: 3.597

3. Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model.

Authors: DaWon Kim; Jeong Hwa Lee; Hye Yun Kim; Jisu Shin; Kyeonghwan Kim; Sejin Lee; Jinwoo Park; JinIkyon Kim; YoungSoo Kim
Journal: PLoS One Date: 2020-12-23 Impact factor: 3.240

4. Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process.

Authors: Guiyun Duan; Hao Liu; Liqing Zhang; Chunhao Yuan; Yongchao Li; Yanqing Ge
Journal: RSC Adv Date: 2021-07-23 Impact factor: 4.036

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.

1. Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol.

2. Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo.

3. Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model.

4. Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process.

Review 5. Synthesis of Chalcones Derivatives and Their Biological Activities: A Review.

6. Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents.

7. Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones.

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents.

1. Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol.

2. Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo.

3. Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model.

4. Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process.

Review 5. Synthesis of Chalcones Derivatives and Their Biological Activities: A Review.

6. Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents.

7. Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones.

4. Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process.