Nao Sonoda1, Akiko Morimoto2, Yukako Tatsumi3, Kei Asayama3, Takayoshi Ohkubo3, Satoshi Izawa4, Yuko Ohno5. 1. Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. Electronic address: 25b16803@sahs.med.osaka-u.ac.jp. 2. Department of Fundamental Nursing, Graduate School of Nursing, Osaka Prefecture University, Habikino, Japan. 3. Department of Hygiene and Public Health, Teikyo University, Itabashi-ku, Japan. 4. Saku Central Hospital, Saku, Japan. 5. Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Japan.
Abstract
BACKGROUND: To assess the impact of diabetes on restrictive and obstructive lung function impairment. METHODS: This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians. Restrictive and obstructive lung function impairment were defined as forced vital capacity (FVC) <80% predicted and forced expiratory volume in 1s (FEV1) to FVC ratio (FEV1/FVC) <0.70, respectively. Participants were screened until they developed restrictive or obstructive lung function impairment or until March 2014. RESULTS: During the follow-up period, 171 and 639 individuals developed restrictive and obstructive lung function impairment, respectively. Individuals with diabetes had a 1.6-fold higher risk of restrictive lung function impairment than those without diabetes after adjusting for sex, age, height, abdominal obesity, smoking status, exercise habits, systolic blood pressure, HDL-cholesterol, log-transformed high-sensitivity C-reactive protein, and baseline lung function [multivariable-adjusted HR and 95% CI; 1.57 (1.04-2.36)]. In contrast, individuals with diabetes did not have a significantly higher risk of obstructive lung function impairment [multivariable-adjusted HR and 95% CI; 0.93 (0.72-1.21)]. CONCLUSION: Diabetes was associated with restrictive lung function impairment but not obstructive lung function impairment.
BACKGROUND: To assess the impact of diabetes on restrictive and obstructive lung function impairment. METHODS: This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians. Restrictive and obstructive lung function impairment were defined as forced vital capacity (FVC) <80% predicted and forced expiratory volume in 1s (FEV1) to FVC ratio (FEV1/FVC) <0.70, respectively. Participants were screened until they developed restrictive or obstructive lung function impairment or until March 2014. RESULTS: During the follow-up period, 171 and 639 individuals developed restrictive and obstructive lung function impairment, respectively. Individuals with diabetes had a 1.6-fold higher risk of restrictive lung function impairment than those without diabetes after adjusting for sex, age, height, abdominal obesity, smoking status, exercise habits, systolic blood pressure, HDL-cholesterol, log-transformed high-sensitivity C-reactive protein, and baseline lung function [multivariable-adjusted HR and 95% CI; 1.57 (1.04-2.36)]. In contrast, individuals with diabetes did not have a significantly higher risk of obstructive lung function impairment [multivariable-adjusted HR and 95% CI; 0.93 (0.72-1.21)]. CONCLUSION:Diabetes was associated with restrictive lung function impairment but not obstructive lung function impairment.
Authors: Daniel C Chambers; Andreas Zuckermann; Wida S Cherikh; Michael O Harhay; Don Hayes; Eileen Hsich; Kiran K Khush; Luciano Potena; Aparna Sadavarte; Tajinder P Singh; Josef Stehlik Journal: J Heart Lung Transplant Date: 2020-07-30 Impact factor: 10.247
Authors: James G Wagner; Christina E Barkauskas; Aaron Vose; Ryan P Lewandowski; Jack R Harkema; Robert M Tighe Journal: Environ Health Perspect Date: 2020-11-30 Impact factor: 9.031