Literature DB >> 29288680

Deciphering sex differences in the immune system and depression.

Jennifer R Rainville1, Mariya Tsyglakova2, Georgia E Hodes3.   

Abstract

Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribution of gonadal and stress hormones to immune function at the cellular and molecular level in the brain and body. We propose hormonal and genetic sex specific immune mechanisms that may contribute to the etiology of mood disorders.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Depression; Estrogen; Immune function; Progesterone; Stress; Testosterone

Mesh：

Substances：

Year:  2017        PMID： 29288680     DOI： 10.1016/j.yfrne.2017.12.004

Source DB:  PubMed          Journal:  Front Neuroendocrinol        ISSN： 0091-3022            Impact factor:   8.606


  13 in total

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9.  Plasma androgens and the presence and course of depression in a large cohort of women.

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Review 10.  Sex differences in neuroimmune and glial mechanisms of pain.

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