| Literature DB >> 29288328 |
Keiko Ogawa1, Seikou Nakamura1, Kohei Hosokawa1, Hanako Ishimaru1, Natsuki Saito1, Kaori Ryu1, Masahiro Fujimuro1, Souichi Nakashima1, Hisashi Matsuda2.
Abstract
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V-VIII were isolated. The structural determination of new compounds damasterpenes V-VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.Entities:
Keywords: Antiviral activity; Diterpene; HSV-1; Nigella damascena; Ranunculaceae
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Year: 2017 PMID： 29288328 DOI： 10.1007/s11418-017-1166-6
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343