Literature DB >> 2928780

Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity.

L K Silbart1, D F Keren.   

Abstract

A secretory immune response to the carcinogen 2-acetylaminofluorene (AAF) was elicited in rabbits by directly immunizing the small intestine with an AAF-cholera toxin conjugate. High-titer, high-affinity secretory immunoglobulin A (IgA) antibody to AAF was secreted into the intestinal lumen in response to this immunogen. Immune secretions reduced the transepithelial absorption of a 125I-labeled derivative of AAF by more than half. This reduction of absorption by hapten-specific IgA suggests that oral vaccines against carcinogens and toxicants could be developed for humans.

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Year:  1989        PMID： 2928780     DOI： 10.1126/science.2928780

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Secretory IgA in saliva can be a useful stress marker.

Authors:  S Tsujita; K Morimoto
Journal:  Environ Health Prev Med       Date:  1999-04       Impact factor: 3.674

2.  Generation of antibodies reactive with fumonisins B1, B2, and B3 by using cholera toxin as the carrier-adjuvant.

Authors:  J I Azcona-Olivera; M M Abouzied; R D Plattner; W P Norred; J J Pestka
Journal:  Appl Environ Microbiol       Date:  1992-01       Impact factor: 4.792

3.  Production of polyclonal antibodies to the trichothecene mycotoxin 4,15-diacetylnivalenol with the carrier-adjuvant cholera toxin.

Authors:  M M Abouzied; J I Azcona-Olivera; T Yoshizawa; J J Pestka
Journal:  Appl Environ Microbiol       Date:  1993-05       Impact factor: 4.792

4.  Modulation of DNA binding in vivo by specific humoral immunological response: a novel host factor in environmental carcinogenesis?

Authors:  A Verdina; R Zito; G Cortese; A Zijno; R Crebelli
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

5.  Idiotypic and anti-idiotypic antibodies against polycyclic aromatic hydrocarbon in human blood serum are new biomarkers of lung cancer.

Authors:  Ivan S Grebenshchikov; Valentin A Ustinov; Artem E Studennikov; Vadim I Ivanov; Natalia V Ivanova; Victor A Titov; Natalja E Vergbickaya
Journal:  Oncotarget       Date:  2019-08-20

Review 6.  Immunomodulation of carcinogens-induced steroids-dependent human diseases.

Authors:  Andrew N Glushkov; Elena G Polenok
Journal:  Saudi J Biol Sci       Date:  2017-10-03       Impact factor: 4.219

Review 7.  The B-cell system of human mucosae and exocrine glands.

Authors:  P Brandtzaeg; I N Farstad; F E Johansen; H C Morton; I N Norderhaug; T Yamanaka
Journal:  Immunol Rev       Date:  1999-10       Impact factor: 12.988

8.  Exposure to aflatoxin B1 in animal-feed production plant workers.

Authors:  J L Autrup; J Schmidt; H Autrup
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031

9.  Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab).

Authors:  Heather Wanczyk; Tolga Barker; Debra Rood; Daniel I Zapata; Amy R Howell; Stewart K Richardson; John Zinckgraf; Gregory P Marusov; Michael A Lynes; Lawrence K Silbart
Journal:  Toxins (Basel)       Date:  2013-03-19       Impact factor: 4.546
  9 in total

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