| Literature DB >> 29287712 |
Lian Duan1, Junyuan Hu1, Xingjiang Xiong2, Yongmei Liu2, Jie Wang3.
Abstract
Epigenetic studies have identified DNA methylation in coronary artery disease (CAD). How the critical genes interact at the cellular level to cause CAD is still unknown. The discovery of DNA methylation inspired researchers to explore relationships in genomic coding and disease phenotype. In the past two decades, there have been many findings regarding the relationship between DNA methylation and CAD development, and the DNA methylation of critical genes have been found to be significantly changed during CAD, including DNA methylation at homocysteine, Alu and long Interspersed Element 1 (LINE-1) repetitive elements. Here, we provide a brief overview of the biology and mechanisms of DNA methylation and its roles in CAD. We also discuss recent findings regarding DNA methylation of homocysteine, Alu and LINE-1 and some genes on CAD in vitro and in vivo. Finally, we provide some perspectives on DNA methylation in CAD.Entities:
Keywords: Alu; CAD; DNA methylation; Homocysteine; LINE-1
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Year: 2017 PMID： 29287712 DOI： 10.1016/j.gene.2017.12.033
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688