Literature DB >> 29287624

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

Claire Vennin1, Kendelle J Murphy1, Jennifer P Morton2, Thomas R Cox1, Marina Pajic3, Paul Timpson4.   

Abstract

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Diagnostic Tool; Invasion; Metastasis; Pancreatic Cancer; Patient-Derived Models; Stromal Remodeling

Mesh：

Substances：

Year:  2017        PMID： 29287624     DOI： 10.1053/j.gastro.2017.11.280

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  65 in total

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Authors:  Thomas R Cox
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10.  Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.

Authors:  Ivana Peran; Sivanesan Dakshanamurthy; Matthew D McCoy; Anastasia Mavropoulos; Bedilu Allo; Aimy Sebastian; Nicholas R Hum; Sara C Sprague; Kelly A Martin; Michael J Pishvaian; Eveline E Vietsch; Anton Wellstein; Michael B Atkins; Louis M Weiner; Andrew A Quong; Gabriela G Loots; Stephen S Yoo; Shahin Assefnia; Stephen W Byers
Journal:  Gastroenterology       Date:  2020-12-09       Impact factor: 22.682
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