| Literature DB >> 29287258 |
Nailiang Zhu1, Zhonghao Sun1, Meigeng Hu1, Yedan Li2, Dawei Zhang3, Haifeng Wu1, Yu Tian1, Pengfei Li1, Junshan Yang1, Guoxu Ma4, Xudong Xu5.
Abstract
The tubers of the medicinal plant Hemsleya penxianensis (Cucurbitaceae) yielded 11 cucurbitane-type triterpenes Xuedanencins A-K by silica gel column, ODS column, and pre-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Separated compounds were evaluated for cytotoxic activity against the Hela human cancer cell line and compounds 7 and 8 showed significant cytotoxicity with IC50 values at 1.82 and 2.45 μM, respectively.Entities:
Keywords: Cucurbitane-type triterpenes; Cytotoxic activity; Hemsleya penxianensis (Cucurbitaceae)
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Year: 2017 PMID： 29287258 DOI： 10.1016/j.phytochem.2017.12.014
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072